In search for the molecular mechanisms underlying the formation of the major dense line in peripheral nerve myelin we investigated mice deficient in the myelin proteins P0 and MBP. In mice lacking both molecules axons were enwrapped by myelin-like processes devoid of the major dense line, while mice deficient in either protein showed, respectively, partial and normal compaction. Mice heterozygo...

In this paper we use a natural forcing to construct a left-separated topology on an arbitrary cardinal κ. The resulting left-separated space Xκ is also 0-dimensional T2, hereditarily Lindelöf, and countably tight. Moreover if κ is regular then d(Xκ) = κ, hence κ is not a caliber of Xκ, while all other uncountable regular cardinals are. This implies that some results of [A] and [JSz] are, consis...

In asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. If this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. In order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalat...

Background: Peer evaluation in software engineering (SE) project courses enhances the learning experience of students. It also helps instructors monitor and assess both teams individual evaluations might influence way students work; therefore, quality peer should be tracked through course. xmln...

objective(s): in recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. we examined the practical applicability of the urinary levels of nag (n-acetyl-β-d-glucosaminidase), ap (alkaline phosphatase), and ldh (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated wi...

background maintenance of the adequate intraoperative renal perfusion is very important during orthotopic liver transplantation (olt) to prevent acute renal failure. objectives for the first time, this study was designed to survey the effects of octreotide on urine output during anesthesia for olt and early postoperative renal function. patients and methods in this randomized double-blind place...

there are several problems associated with the use of indwelling urethra catheters, including urinary tract infections and mechanical problems. infections have been well researched but mechanical problems associated with blockage, leakage of urine and general discomfort have been less investigated. although education of patients and carers on the use of catheters has been recommended, in practi...

We show how to apply a general theoretical approach to nonequilibrium statistical mechanics, called Maximum Caliber, originally suggested by E. T. Jaynes [Annu. Rev. Phys. Chem. 31, 579 (1980)], to a problem of two-state dynamics. Maximum Caliber is a variational principle for dynamics in the same spirit that Maximum Entropy is a variational principle for equilibrium statistical mechanics. The ...