background stress urinary incontinence (sui), the most common type of urinary incontinence (ui), is usually defined as leakage of urine during movement or activity which puts pressure on the bladder, such as coughing, sneezing, running or heavy lifting. it is reported in most countries that 15% to 40% of women struggle with sui and its severe implications for daily life, including social intera...

in this paper, a general introduction is given, presenting the overactive bladder syndrome (oab) and its impact on the quality of life and economical burden in patients affected. moreover, the anatomy, physiology and histology of the lower urinary tract are discussed, followed by a brief overview on the possible role of prostaglandin (pg) and phosphodiesterase type 5 (pde5) in the urinary bladd...

results during the period from jan 2000 to dec 2011, at our center, 19 children less than eighteen years of age underwent urinary diversion with yang-monti’s catheterizable stoma. the indications for urinary diversion was neuropathic bladder in eight, exstrophy bladder in seven , valve bladder syndrome in three and persistent urethral stricture in one. none of the children found cic difficult d...

Gerhard A. Müller, Medical University Clinics, Department 3, University of Tübingen, D-7400 Tübingen (FRG) Dear Sir, Diagnosis of kidney disorders so far mainly relies on proteinuria measurements, changes in serum creatinine levels, urine output and release of various serum proteins or renal enzymes into the urine following renal injury. However, these routine tests are rather unspecific and of...

I.O. OMOTOSHO*, E.N. MADUAGWU AND L.I. OKEKE1 Departments of Biochemistry and Surgery1, College of Medicine, University of Ibadan. Nigeria ___________________________________________________________________________________________________ The formation of urinary dimethylinitrosamine [DMN] in male patients with benign prostatic hyperplasia [BPH] associated with urinary Tract infection [UTI] was...

PURPOSE We attempted to determine whether oral L-arginine, the substrate for nitric oxide synthase, increases nitric oxide synthase activity and cyclic guanosine monophosphate (cGMP) levels in the urine from interstitial cystitis patients. Nitric oxide and cGMP are decreased in urine from interstitial cystitis patients and both induce smooth muscle relaxation and immunological responses. Increa...

The presence of activators of the fibrinolytic system in blood plasma has been assumed for a long time but never convincingly documented by the isolation of characterized and physiologically plausible enzymes. The low catalytic efficiency of previously identified plasma plasminogen activators, which has made their physiological significance uncertain, prompted us to search for other plasma enzy...

Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of key enzymes along this pathway. In this study, we investigated the effect of PPAR activation on circulating and urinary one-carbon metabolites as we...

OBJECTIVE To evaluate renal brush border membrane enzymes in urine as an indicator for renal injury in neonatal scleredema (NS). METHODS Sixty nine NS patients in our hospital were enrolled and divided into mild group and moderate/severe group. Patients were further randomly divided into therapy and control subgroups for 7 days ligustrazine administration. Urine samples were collected to dete...

Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. The aim of this study was to assess serum cystatin C and 2 renal tubular enzymes, neutrophil gelatinase associated lipocalin (NGAL) and N-acetyl-beta-D-glucosaminidase (NAG), as screening markers for early renal dysfunction in patients with type 2 diabetes mellitus (T2DM). ROC curve anal...