The purpose of this study was to evaluate the uricosuric and diuretic properties of the new diuretic agent DR-3438. In the conventional clearance studies in urate-loaded dogs, intravenous injection of DR-3438 (3-30 mg/kg) resulted in dose-related increases in fractional excretion of urate (FEua), urine flow and sodium excretion. At doses causing similar natriuresis, tienilic acid (50 mg/kg, i.v...

Idiopathic renal hypouricaemia is an inherited form of hypouricaemia, associated with abnormal renal handling of uric acid. There is excessive urinary wasting of uric acid resulting in hypouricaemia. Patients may be asymptomatic, but the persistent urinary abnormalities may manifest as renal stone disease, and hypouricaemia may manifest as exercise induced acute kidney injury. Here we have iden...

Urate oxidase is an important enzyme with therapeutic and diagnostic applications. Rasburicase is a recombinant urate oxidase enzyme approved by FDA to use in the treatment of hyperuricemia conditions. Various hosts such as Saccharomyces cerevisiae, Hansenula polymorpha and Escherichia coli have been used to express the enzyme. Today, Pichia pastoris is considered as an important host for heter...

Some studied have suggested that serum uric acid predicts coronary heart disease (CHD) (2). However, prospective epidemiological studies have reported apparently conflicting findings, with several studies reporting positive associations only among women (3,4). Wheeler et al (5) reported that serum uric acid levels were unlikely to predict CHD, and this factor was unlikely to be a major determin...

Letter by George Regarding Article, “Uric Acid-Lowering Treatment With Benzbromarone in Patients With Heart Failure: A Double-Blind Placebo-Controlled Cross-Over Preliminary Study” To the Editor: I read with interest the study by Ogino et al1 about the effects of the uricosuric agent benzobromarone in patients with chronic heart failure. It is a well thought out study that further adds to the c...

The geometries and energetics of complexes of Li(+), Na(+), K(+), Be(2+), Mg(2+), and Ca(2+)metal cations with different possible uric acid anions (urate) were studied. The complexes were optimized at the B3LYP level and the 6-311++G(d,p) basis set. Complexes of urate with Mg(2+), and Ca(2+)metal cations were also optimized at the MP2/6-31+G(d) level. Single point energy calculations were perfo...

?18 Composition, &c. Oxalate of lime nucleus, with uric acid and oxalate of lime alternating. Colour, brown and fawn. Structure, laminated. Uric acid nucleus, with uric acid and a little urate of ammonia. Colour, light fawn, Structure, non-laminated, soft. Uric acid throughout. Colour, fawn. Structure, indistinctly laminated. Urate of lime throughout. Colour, grey. Structure, compact, non-lamin...

Urate oxidase (uricozyme) is an enzyme of non-human origin capable of oxidizing human uric acid to allantoin, a highly soluble product at renal tubule pH. We report its efficacy in three patients with acute urate nephropathy due to tumour lysis in chronic lymphatic leukaemia and high grade lymphoma. Two patients had an additional obstructive nephropathy due to ureteric urate crystals. An intrav...

Transmission electron microscopic studies of synthetic and natural monosodium urate crystals dried on formvar coated grids showed identical internal structures in all crystals. At higher magnification the crystals' surface showed angular or wavy irregularities, and more rarely some crystals appeared to have other tiny crystals on the surface. Protein-like surface coating was not observed except...

INTRODUCTION Both sugar-sweetened beverage (SSB) intake and body mass index (BMI) are associated with elevated serum urate concentrations and gout risk. The aim of this study was to determine whether the associations of SSB intake with serum urate and gout are moderated by BMI. METHOD The effects of chronic SSB intake on serum urate and gout status were analysed in a large cross-sectional pop...