The highly conserved ubiquitin-proteasome system (UPS) controls the stability of most nuclear and cytoplasmic proteins and is therefore essential for virtually all aspects of cellular function. We have previously shown that the UPS is impaired in the presence of aggregated proteins that become deposited into cytoplasmic inclusion bodies (IBs). Here, we report that production of protein aggregat...

Maintenance of protein quality control is a critical function of the ubiquitin proteasome system (UPS). Evidence is rapidly mounting to link proteasome dysfunction with a multitude of cardiac diseases, including ischemia, reperfusion, atherosclerosis, hypertrophy, heart failure, and cardiomyopathies. Recent studies have demonstrated a remarkable level of complexity in the regulation of the UPS ...

Beliefs in cover-ups take the perspective of conspiracy theories. This study examined demographic, ideological, and work-related attitudes (disenchantment, equity sensitivity) ideas about events being covered up. Over 500 working adults completed a number questionnaires including beliefs official conspiracies (CT), disenchantment, sensitivity to equity, personal demography as well religious pol...

BACKGROUND Transforaminal lumbar interbody fusion (TLIF) is an effective surgery for lumbar degenerative disease. However, this fusion technique requires resection of inferior facet joint to provide access for superior facet joint resection, which results in reduced lumbar spinal stability and unnecessary trauma. We have previously developed extraforaminal lumbar interbody fusion (ELIF) that ca...

PURPOSE The minimally invasive transforaminal lumbar interbody fusion procedure with percutaneous pedicle screws was adopted in clinical practice, but the choice between a unilateral pedicle screw (UPS) or bilateral pedicle screw (BPS) fixation after lumbar fusion remains controversial. The purpose of the present retrospective study was to compare the clinical outcomes and radiological results ...

Digital mock-ups (DMU) are the platform for Virtual Prototyping (VP). Therefore, questions concerning VP are focused on the integration of computer-based tools and methods for DMU. Which reliability concerning the assessment of product characteristics do digital mock-ups have? What kind of representation/visualization is necessary to achieve a high reliability [4] concerning the assessment of p...

n this issue of Circulation: Cardiovascular Quality and Outcomes, Xu et al present findings from a search of US patents related to bare-metal coronary stents in an effort to gain insight on how medical device innovation starts and how policies in the United States might help to promote more innovation. 1 Of the 245 patents identified by their search strategy for the years 1984 to 1994, the auth...

Operations research specialists at UPS and the Massachusetts Institute of Technology (MIT) created a system to optimize the design of service networks for delivering express packages. The system simultaneously determines aircraft routes, fleet assignments, and package routings to ensure overnight delivery at minimal cost. It has become central to the UPS planning process, fundamentally transfor...

We propose a novel method for mitigating erroneous wake-ups that are commonly associated with ultra-low power wake-up receivers. Recent research in low-power protocols has demonstrated significant improvements in energy-efficiency by employing ultralow power wake-up receivers. However, due to the low-complexity receiver structures adopted, wake-up receivers are susceptible to external interfere...

BACKGROUND Little evidence exists on the efficacy and safety of the different surgical techniques used in the treatment of postpartum haemorrhage (PPH). We aimed to compare uterus preserving surgery (UPS) versus hysterectomy for refractory PPH in terms of perioperative outcomes in a sub-Saharan African country with a known high maternal mortality ratio due to PPH. METHODS This was a retrospec...