The paper advocates the use of a statistical tool dedicated to the exploration of data samples populated by several sources of events. This new technique, called sP lot, is able to unfold the contributions of the different sources to the distribution of a data sample in a given variable. The sP lot tool applies in the context of a Likelihood fit which is performed on the data sample to determin...

The BioSamples Database aggregates information for reference samples (such as cell lines or stock strains), as well as samples for which data exist in one of the EBI's other data resources (e.g. ArrayExpress [2], the European Nucleotide Archive [3], PRIDE [4]). Samples are described with a set of annotations. These annotations can be linked to ontology [5] (or controlled vocabulary [6]) terms, ...

Main library for Southern Illinois University Carbondale [2] Holds more than 2.6 million volumes, 200,000 e-books, 43,000 current periodicals and serials, and over 3.6 million microform units Provides access to I-Share [3] (the statewide automated library system) and to a comprehensive array of databases and other electronic data files Offers a wide range of services, including Reference assist...

Why do we need EMPIAR? EMPIAR provides a way to easily access state-of-the-art 2D image data that underpins 3D cryo-EM structures of biomacromolecules [6] and molecular machines. It complements the Electron Microscopy Data Bank (EMDB [7]), where corresponding 3D structures are stored, and PDB [8] which stores atomic models of macromolecular structures (Figure 1). EMPIAR data has been used to fa...

Classifying proteins into families and identifying important domains and sites is invaluable for helping biologists to identify distantly related proteins and to predict their functions. A daunting array of resources, each with different strengths and weaknesses, is now available for searching genomes and proteomes with ‘protein signatures’ – diagnostic entities that are used to recognise a par...

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UniProt Knowledgebase [2]: a databse of protein sequence and functional information; Protein Data Bank in Europe (PDBe [3]): a database of protein structures; Rhea [4]: a database of enzyme-catalysed reactions; Reactome [5]: a database of biological pathways; IntEnz [6]: a resource with enzyme nomenclature information; ChEBI [7] and ChEMBL [8]: resrouces that contain information about small mol...

Main library for Southern Illinois University Carbondale [2] Holds more than 2.6 million volumes, 200,000 e-books, 43,000 current periodicals and serials, and over 3.6 million microform units Provides access to I-Share [3] (the statewide automated library system) and to a comprehensive array of databases and other electronic data files Offers a wide range of services, including Reference assist...

Main library for Southern Illinois University Carbondale [2] Holds more than 2.6 million volumes, 200,000 e-books, 43,000 current periodicals and serials, and over 3.6 million microform units Provides access to I-Share [3] (the statewide automated library system) and to a comprehensive array of databases and other electronic data files Offers a wide range of services, including Reference assist...

Williams syndrome...people with intact language, intact face processing and very low IQ, right? Wrong! That’s the propagated myth because, if it were true, it would be such an elegant example of innate modularity at the genetic, brain and cognitive levels. But numerous labs across the world have shown that although vocabulary levels can be surprisingly high in Williams syndrome children, they a...