Apoptosis and glutamate-mediated excitotoxicity may play a role in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease (PD). In the present study, we investigated whether stimulation of the 5-hydroxytryptamine 1A (5-HT1A) receptor attenuates N-methyl-D-aspartate- (NMDA) and 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptotic cell death in cell culture models. ...

A 60-years old patient was admitted to a community hospital with septic arthritis. He was treated with antibiotics and subcutaneous unfractionated heparin (UH) was used for venous thromboprophylaxis. After three days, he developed leg deep venous thrombosis and was treated with IV heparin. One day later, the patient developed pulmonary emboli, which was found using ventilation/perfusion scan. H...

The main factors affecting the accurate and precise determination of U using ICP-MS are instrumental background, the isobaric interference of UH molecular ion on U analyte ions, and the presence of U and U peak tails. An optimized analytical method for attenuating the influence of these factors on uranium isotope ratio measurements at ultratrace level of environmental samples has been developed...

Like the Coxeter graph became reattached into the Klein graph in [3], the Levi graphs of the 93 and 103 self-dual configurations, known as the Pappus and Desargues (k-transitive) graphs P and D (where k = 3), also admit reattachments of the distance-(k − 1) graphs of half of their oriented shortest cycles via orientation assignments on their common (k−1)-arcs, concurrent for P and opposite for ...

and Applied Analysis 3 for all uh x ∈ Uh, where φi x is the basis function associated with the nodes xi i 1, 2, . . . , r − 1 , φi x ⎧ ⎪ ⎪⎨ ⎪ ⎪⎩ 1 − xi − x hi , x ∈ Ii, 1 − x − xi hi 1 , x ∈ Ii 1, 0, x / ∈ Ii ∪ Ii 1. 2.1 It is easy to know that the derivative of uh with respect to x is uhx x uh xi − uh xi−1 hi , xi−1 ≤ x ≤ xi, i 1, 2, . . . , r. 2.2 The test function space Vh ⊂ L2 I associated ...

Wittke et al. (1) present evidence of a major cosmic impact at the onset of the Younger Dryas (YD) episode, including some markers found in the top of the well-known Usselo marker horizon (UH). This finding is contrary to our extensive radiocarbon dating effort from this horizon (2), which shows that the UH at Aalsterhut postdates the onset of the YD. Furthermore, Wittke et al. (1) misinterpret...

Abstract Funding Acknowledgements Type of funding sources: None. Background Since setting up the cardiac electrophysiology (EP) service at our tertiary centre (UH) in 2010, there has been a significant increase referrals for EP procedures especially catheter ablation atrial fibrillation (AF). UH serves catchment area above 1 million people and increasing demand coupled with limited resources pu...

The Langevin system is an important mathematical model to describe Brownian motion. research shows that fractional differential equations have more advantages in viscoelasticity. exploration of dynamics novel and valuable. Compared with the Caputo or Riemann–Liouville (RL) derivatives, Mittag–Leffler (ML)-type derivatives can eliminate singularity such solution has better analytical properties....

Abstract Approximately 1–3 violent tornadoes hit Europe each decade. We use the ERA5 reanalysis and WRF model to reconstruct environments for 12 cases between 1957 2021. Violent in occur a variety of synoptic mesoscale patterns, but they share environmental similarities with significant from United States. Downscaling simulations 3 km grid‐spacing showed added value improved resolution represen...

Let g be a complex semisimple Lie algebra, and let G be a complex semisimple group with trivial center whose root system is dual to that of g. We establish a graded algebra isomorphism H q (Xλ,C) ∼= Sg e/Iλ, where Xλ is an arbitrary spherical Schubert variety in the loop Grassmannian for G, and Iλ is an appropriate ideal in the symmetric algebra of g, the centralizer of a principal nilpotent in...