This article introduces and critically reflects upon the development of CiviAct – a multi-agency project that partners six anti-racist activist organisations two universities in North England. seeks to support realise benefits youth community-led civic action. It does this by: (i) financially resourcing work organisations; (ii) connecting those with each other create new opportunities for co-le...

We have shown previously that continuous (6 days) intracerebroventricular (ICV) leptin infusion in normal rats resulted in decreases in food intake and body weight. A reduction of food intake imposed on control rats (pair-feeding), aimed at mimicking leptin-induced hyperphagia, produced a marked decrease in the expression of muscle uncoupling protein-3 (UCP-3), whereas ICV infusion of leptin pr...

To understand the role of mitochondrial uncoupling protein (UCP) in regulating insulin signaling and glucose homeostasis, we created transgenicDrosophila lines with targeted UCP expression in insulin producing cells (IPCs). Increased UCP activity in IPCs results in decreased steady state Ca(2+) levels in IPCs as well as decreased PI3K activity and increased FoxO nuclear localization in peripher...

Background—Obesity and diabetes mellitus are complex metabolic problems of pandemic proportion, contributing to significant cardiovascular mortality. Recent studies have shown altered mitochondrial function in the hearts of diabetic animals. We hypothesized that regulatory events involved in the control of mitochondrial function are activated in the prediabetic, insulin-resistant stage. Methods...

Samples of adipose tissue were obtained from different sites in bovine and ovine foetuses and newborns. RNA was isolated and analysed using bovine cDNA and ovine genomic probe for uncoupling protein (UCP), cDNA for subunits III and IV of cytochrome c oxidase and cDNA for ADP/ATP carrier. UCP mRNA was characterized for the first time in foetal bovine and ovine adipose tissue. It appeared later t...

Uncoupling proteins (UCPs) are members of the anion carrier protein family that are present in the mitochondrial inner membrane and mediate a proton conductance dissipating the mitochondrial electrochemical proton gradient. A physiological function of the first described UCP, UCP1 or termogenin, present in mitochondria of mammalian brown adipose tissue is participation in nonshivering thermogen...

Background and Objective: Today, obesity is one of the most important health problems in the world. The purpose of this study was to determine the effects of caffeine and high fat diet on expression of PGC1-α, Fndc-5 and UCP-1 genes in male Wistar rats. Materials and Methods: To study the aim of this survey, 40 male Wistar rats were divided into four equal groups (n=10 in each group), includin...