Insulin treatment in adult type I diabetic patients decreases protein loss primarily by inhibiting protein breakdown without stimulating protein synthesis. In young growing rodents, insulin treatment has been reported to stimulate protein synthesis. We examined whether insulin stimulates protein synthesis in normally growing prepubertal children with insulin-dependent diabetes mellitus. Five pr...

abstract background: better control of blood sugar and reduction of diabetes complications through insulin therapy could convince people to choose this method. however, patients might refuse insulin therapy due to its painful injection, limitations in daily activities, and hypoglycemia. thus, insulin therapy could have both positive and negative effects on patients’ quality of life (qol). there...

Diabetes mellitus refers to a group of metabolic diseases that share the hallmark characteristic of hyperglycemia. Generally, Diabetes is categorized as type I, or type II. Type I results from the body's failure to synthesize insulin, and requires insulin injections. Type II, also known as adult-onset or non-insulin dependent diabetes mellitus (NIDDM), occurs when the body's cells fail to use i...

Insulin-like growth factors I and II (IGF-I and II) and insulin are chemotactic agents for the human melanoma cell line A2058. As shown in this report, the motility receptor mediating this response is the heterodimeric type I IGF receptor. These three factors are able to compete with 125I-labeled IGF-I for binding to the cell surface with IC50 values equal to approximately 2 (IGF-I), approximat...

AIMS/HYPOTHESIS There is controversy with respect to molecular characteristics of insulin analogues. We report a series of experiments forming a comprehensive characterisation of the long acting insulin analogues, glargine and detemir, in comparison with human insulin, IGF-1, and the super-mitogenic insulin, X10. METHODS We measured binding of ligands to membrane-bound and solubilised recepto...

Insulin deficiency in type I diabetes may lead to cognitive impairment, cerebral atrophy and white matter abnormalities. We studied the impact of a novel delivery system using intranasal insulin (I-I) in a mouse model of type I diabetes (streptozotocin-induced) for direct targeting of pathological and cognitive deficits while avoiding potential adverse systemic effects. Daily I-I, subcutaneous ...

We analyzed extended haplotypes composed of DNA loci on the short arm of chromosome 11 for segregation with insulin-dependent (type I) diabetes mellitus. The markers for these loci are tyrosine hydroxylase, insulin, and c-Ha-ras-1 proto-oncogene (HRAS1). We report, in a study of 27 families, that a specific haplotype (H), containing a 3-kilobase (kb) HRAS1-Taq I DNA polymorphism, segregated dif...