Despite improved awareness of work-related diseases and preventive measures, many workers are still at high risk of developing occupational hypersensitivity airway diseases. This stems from a lack of knowledge of bioaerosol composition and their potential effects on human health. Recently, archaea species were identified in bioaerosols, raising the possibility that they play a major role in exp...

T cell-dependent activation of resident tissue mast cells is required for the elicitation of delayed-type hypersensitivity skin reactions in mice. A T cell-derived antigen-binding factor that transfers the ability to elicit an immediate hypersensitivity-like skin reaction is described and compared with a hybridoma IgE antibody. Both the T cell factor and IgE mediate reactions with increased vas...

Hypersensitivity reactions are classified into four groups (Type I, II, III, and IV), each characterized by specific biological actions. Research has focused on understanding each hypersensitvity to ensure appropriate therapeutic recommendations are made. This overview will present the defining characteristics of each hypersensitivity and examine the diagnostic methods used to determine the exi...

To the Editor: In the very interesting review published in Circulation dealing with cardiac complications of chemotherapy with a focus on myocardial complications, the authors did not refer to the cardiac hypersensitivity that is associated with chemotherapy. Acute cardiovascular events associated with hypersensitivity to chemotherapeutic drugs pose a real threat for the myocardium. Rare and ve...

We tested two biological properties of a continuously growing mouse cytotoxic T cell line, L4, which is specific for influenza A virus and has been cloned and recloned many times. We previously reported that L4 cells are H-2 restricted and cross-reactive for all type A influenza viruses, whereas they do not recognize type B influenza viruses. They bear Thy-1 and Lyt-2 markers. In the present st...

BACKGROUND The purpose of the present study was to determine whether T cell-mediated type IV hypersensitivity reactions could be a major cause of adverse reaction to metal debris (ARMD) after metal-on-metal total hip arthroplasty (THA). METHODS Thirteen patients (1 man and 12 women; mean age 68 years, age range 60 to 83 years) with ARMD underwent revision surgery following metal-on-metal THA ...