Androgen-independent metastatic prostate cancer is the main obstacle in the treatment of this cancer. Unlike a majority of solid cancers, prostate cancer usually shows poor response to chemotherapeutic drugs. In this study, we have shown a potential novel target, TWIST, a highly conserved bHLH transcription factor, in the treatment of prostate cancer. Using malignant and nonmalignant prostate t...

One of the first steps in embryonic mesodermal differentiation is allocation of cells to particular tissue fates. In Drosophila, this process of mesodermal subdivision requires regulation of the bHLH transcription factor Twist. During subdivision, Twist expression is modulated into stripes of low and high levels within each mesodermal segment. High Twist levels direct cells to the body wall mus...

Patients with low-grade myelodysplastic syndromes (MDS) show high levels of tumor necrosis factor (TNF ) and upregulation of apoptosis in the marrow. In contrast, marrow cells in advanced MDS are typically resistant to TNF -induced apoptosis but are rendered apoptosissensitive on coculture with stroma. The present studies show that CD34 marrow cells in advanced MDS express high levels of TWIST,...

We investigate the twist-3 effects in the polarized virtual photon structure. The structure functions g 1 and g γ 2 of polarized photon could be experimentally studied in the future polarized ep or ee colliders. The leading contributions to g 1 are the twist-2 effects, while another structure function g 2 , which only exists for the virtual photon target, receives not only the twist-2 but also ...

Introduction Left ventricular (LV) twist is believed to store potential energy and plays an important role in generating diastolic suction. Recent advances in echocardiography techniques have allowed quantification of LV twist. The aim of the present study was to compare LV twist and torsion in healthy human subjects determined by velocity vector imaging (VVI) and tissue Doppler imaging (TDI) a...

‎‎in the category of mordell curves (e_d:y^2=x^3+d) with nontrivial torsion groups we find curves of the generic rank two as quadratic twists of (e_1), ‎and of the generic rank at least two and at least three as cubic twists of (e_1). ‎previous work‎, ‎in the category of mordell curves with trivial torsion groups‎, ‎has found infinitely many elliptic curves with rank at least seven as sextic tw...

BACKGROUND Recent studies hypothesized left ventricular (LV) twist as a potential biomarker for evaluation of sub clinical myocardial disease, however its relationship with aortic stiffness has yet to be investigated. Chronic kidney disease (CKD) has been identified as a risk factor for both myocardial and arterial disease. As such we sought to explore the relationship between aortic stiffness ...

Numerous reports have now demonstrated that the epithelial-to-mesenchymal transition (EMT) process is involved in solid tumor progression, metastasis, and drug resistance. Several transcription factors have been implicated as drivers of EMT and metastatic progression, including Twist. Overexpression of Twist has been shown to be associated with poor prognosis and drug resistance for many carcin...

We investigate the twist-3 light-cone distribution amplitudes (LCDAs) of the scalar mesons a0, K∗ 0 and f0 within the QCD sum rules. The QCD sum rules are improved by a consistent treatment of the sizable s-quark mass effects within the framework of the background field approach. Adopting the valence quark component (q̄1q2) as the dominant structure of the scalar mesons, our estimation for their...

Certain bacteria form filamentous colonies when the cells fail to separate after dividing. In Bacillus subtilis, Bacillus thermus, and Cyanobacteria, the filaments can wrap into complex supercoiled structures as the cells grow. The structures may be solenoids or plectonemes, with or without branches in the latter case. Any microscopic theory of these morphological instabilities must address the...