BACKGROUND Reactive oxygen species (ROS) have been proposed to play important pathogenic roles, especially in harmful oxidative modifications of low-density cholesterol. Redox balance within the organism is largely determined by the activities of anti-oxidative enzymes of red blood cells and by the total anti-oxidative capacity of the serum (TAS). MATERIAL/METHODS SOD and GPx activities and T...

The objective is to select the best anthropometric measurements to characterize a healthy elderly population. For that, 1030 healthy elderly persons (508 men and 522 women) living independently or in an institution (in both public and private homes) were enrolled for this population-based, cross-sectional study conducted from February 2004 to May 2005. Anthropometric measurements were made by t...

objectives: the aim of this study was to investigate the effects of gender on plasma myostatin at rest and in response to acute resistance exercise in elderly men and women. methods & materials: 12 healthy older men (age=69±1.23 and bmi=23±0.3 kg/m2) and 12 healthy older women (age=68±2.14 and bmi=23±0.4 kg/m2) volunteered for participation in this study. 72hours after the determination of musc...

AIMS Heart rate variability has been proposed as an indicator of cardiovascular health. Since women have a lower cardiovascular risk, we hypothesized that there are gender differences in autonomic modulation. METHODS AND RESULTS In 276 healthy subjects (135 women, 141 men) between 18 and 71 years of age, 24 h heart rate and heart rate variability were determined. All heart rate variability pa...

PURPOSE To investigate by laser scanning confocal microscopy (LSCM) the density of presumed epithelial, presumed goblet, and presumed inflammatory cells in the tarsal conjunctiva of healthy young and older subjects and in patients with Sjögren's syndrome (SS). To evaluate the interobserver variability and to compare the measured densities with known age-related and SS-related changes. METHODS...

BACKGROUND Few studies have examined how various lifestyle factors in midlife predict longevity, and none of these studies have examined the impact of physical fitness. The present study aimed to examine longevity in relation to smoking, overweight and physical fitness. METHODS We prospectively studied longevity (defined as reaching at least 85 years of age) in relation to smoking status, bod...

Objective(s):The neuropeptide calcitonin gene-related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. Earlier studies showed that CGRP can stimulate the synthesis and release of nitric oxide (NO) and cytokines from trigeminal ganglion glial cells. The purpose of this study was to determine the effect of 17β-estradiol in regulation of CGRP exp...