Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using gain-and-loss of function approaches, we show that miR-103 exacerbates DNA damage and inhibits a...

This paper presents an exploratory study of the potential for offering students elements to construct their own personal learning environments, through a combination of an eportfolio and integrated learning platform. The intention was to integrate an institutional virtual learning environment; an e-portfolio for assembling work, where the students can include ideas and reflections and create th...

Introduction: This paper deals with the key elements that should be included in a personalized learning environment (PLE) to assist tutors in the effective development of online tutoring. Materials and methods: Key elements are defined from a quality management perspective and applied within the context of an action-research study, to develop a tutoring model supported on a personalized learnin...

rhizoxin was achieved by enzymatic approach. Characteristic features of the present synthesis are (1) enantioselective hydrolysis of prochiral P-substituted glutarates with pig liver estemse, and (2) stereoselective cyclichydroboration of the 1,5-diene 8. Enantioand stereoselective synthesis of the right-half segment (1, Cl-Cg) of macrolide antibiotic Rhizoxin is an antitumor antibiotic isolate...

A series of charge compensation investigations on SrS:Cu grown by physical vapor phase are reported. In this study, the trivalent ion, Y, was codoped during SrS growth to substitute on the Sr-site. Although similar EL performance to high temperature annealed sputtered samples was obtained using an annealing temperature of 6508C, our results indicated that the thermal quenching in this material ...

The aim of this qualitative study is to investigate how young citizens engage with urban inquiries activities on Personal Learning Environments (PLEs). This work analyses how educators can design and assess short inquiry activities as well as how students use a PLE to interact and collaborate for creating scientific questions. Participants of this qualitative study were 5 researchers from Highe...

Recent studies have demonstrated an overlap between the neural substrate of resting-state activity and self-related processing in the cortical midline structures (CMS). However, the neural and psychological mechanisms mediating this so-called "rest-self overlap" remain unclear. To investigate the neural mechanisms, we estimated the temporal structure of spontaneous/resting-state activity, e.g. ...

The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. Power laws are well documented in nature in general, particularly in the brain. Some previous fMRI studies have demonstrated a lower PLE during cognitive-task-evoked activity than during resting state acti...

This position paper discusses the evaluation of personal learning environment (PLE) enablers along four main axes including the delivery of personalized and contextualized recommendation services and the flexible representation of interaction and learning contexts.

New power relations and the shift in control have been some of the key topics driving the discussion about Personal Learning Environments (PLE). This paper explores the role of sense of ownership and control in use of technologyenhanced learning environments. The paper is rooted in the theory of psychological ownership and reports on empirical findings from a joint study conducted at universiti...