Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are two oncogenic human γ-herpesviruses that each with 1-2% of tumors. They encode bona fide oncogenes they express during latent infection to amplify their host cells themselves within these. In contrast, lytic particle producing has been considered destroy might be even induced therapeutically eliminate EBV KSHV However...

Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most important angiogenic factor with proven significance in breast cancer, as it has been ...

Antibiotics are considered as a cornerstone of modern medicine and their discovery offers the resolution to infectious diseases problem. However, excessive use antibiotics worldwide has generated critical public health issue bacterial resistance correlated with inefficiency is still unsolved. Finding novel therapeutic approaches overcome imperative, natural compounds antibacterial effects could...

I n a recent analysis of a large observational study, bevacizumab (Avastin), an inhibitor of angiogenesis, was associated with favorable survival rates in patients whose colorectal cancer had already progressed. Those taking bevacizumab with chemotherapy had a median overall survival of 32 months, compared with 20 months for those who did not receive bevacizumab beyond first-line therapy. The d...

Deguelin is a rotenoid isolated from several plant species, which has been reported to have chemopreventive effects in skin, mammary, colon and lung cancers. The effects of deguelin on the proliferation and apoptosis of hepatic cancer cells were assessed by MTT assay and flow cytometric analysis. The growth of hepatic cancer cells (HepG2, Huh7 and SK-Hep1) was inhibited by deguelin in a dose-de...