Objective(s): Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and interferon-γ (...

Background: Tumor necrosis factor- a (TNF-α) is a cytokine that was identified as a factor with a wide range of proinflammatory activities. The expression of bovine TNF-α in mammary tissue during pregnancy seems to have a role in development of the corresponding glands.Objective: Single nucleotide polymorphisms (SNPs) were defined in 3′-flanking region of...

Tumor Necrosis Factor alpha (TNF-α) is a proinflamatory cytokine, closely associated with insulin resistance and related diseases such as type II ketosis and fatty liver of cows. Aim of the presented study was to investigate circulating levels of TNF-α after vaccinating dry cattle with inactive rotavirus, coronavirus and E.coli combined vaccine. 14 cattle were randomly assigned to two groups; v...

cytokines play a part in pathogenesis of periodontitis via inflammation phenomenon. aggressive periodontitis (agp) is a multifactorial disease resulting in rapid tooth loss due to severe destruction of tooth supporting apparatus. recently, researchers have focused on genetic susceptibility of periodontitis through investigating the gene variations of cytokines and other components of immune res...

Diet-induced obesity (DIO) is considered the main risk factor for cardiovascular diseases. Increases in plasma levels of tumor necrosis alpha (TNF-α) associated with DIO. Etanercept, a TNF-α inhibitor, has been shown to alleviate cardiac hypertrophy. To investigate effect etanercept on fibrosis DIO model, rats high fat diet (HFD) were subdivided into two groups: group and vehicle group. Cardiac...

Abstract Objectives The data of the monocyte subgroups and expressed toll like receptors (TLR) in innate immune system response, which develop against chronic inflammation patients with predialysis kidney disease (CKD) who undergo dialysis treatment, are limited. We aimed to investigate effect procedure on current inflammatory condition role ratios, expressions TLR2/4 serum Tumor necrosis facto...

In the connection between inflammation and cancer development, tumor necrosis factor-alpha (TNF-α) contributes to the tumorigenesis. However, the underlying mechanism remains poorly understood. In this study, we report that TNF-α enhances the growth of breast cancer through up-regulation of oncoprotein hepatitis B X-interacting protein (HBXIP). Our data showed that the levels of TNF-α were posi...

Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α). In this study, we explored the mechanisms underlying the TNF-α-induced inflammatory ...

In this study, it was aimed to immunohistochemically evaluate the possible effect of probiotic supplementation on rats fed a high cholesterol diet mast cell heterogeneity and density in urinary bladder expression chymase, tryptase tumor necrosis factor-alpha (TNF-α) cytokine bladder. Three groups were formed study. For 8 weeks, Group 1 (control group) regular rat diet. Food for 2 (feeding +2% c...