Abstract OBJECTIVE Medulloblastoma represents one of the most common brain tumors in children. In this study, we identified by BH3 profiling that ONC201/TIC10 sensitizes for Bcl-xL/Bcl-2 inhibition medulloblastoma and performed a preclinical testing combined treatment with inhibitor ABT-263. METHODS was to examine ONC201/TIC10-mediated dependencies on anti-apoptotic Bcl-2 family proteins. The c...

PURPOSE We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. EXPERIMENTAL DESIGN Recombinant human VEGI-192 was produced in Escherichia coli and purified to apparent homogeneity. The protein was given systemically via i.p., i.v., or s.c. injections to tumor-bearing C57BL/6 mice. Tumor growth ra...

Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, we investigate the role of protein kinase C zeta (PKCζ) in pancreatic cancer cells. PKCζ has been shown to act as either a tumor suppressor or tumor promoter depending upon the cellular context. We find that PKCζ expression is either maintained or elevated in primary human pancreatic tumors, but is never...

background : st6gal1, cox-2 and hb-egf genes are involved in different tumors and their enhanced expressions often correlate with poor prognosis. in this study we assay the expressions of these genes by reverse transcriptase-pcr in 54 breast cancer samples. methods : tissue samples were either formalin-fixed for histopathological examination or frozen for reverse transcriptase-pcr. image progra...

The effects of specific dead tumor cell immunization and nonspecific immunostimulation with Corynebacterium parvum on the s.c. growth of the line 1 carcinoma in syngeneic BALB/c mice have been studied. Injection of heavily irradiated line ) carcinoma cells did not inhibit the transplantability or growth of the line 1 carcinoma, and in certain cases these treatments actually prolonged the period...

Abstract Melanoma cells activate Wnt/β-catenin signaling in the tumor microenvironment (TME) to promote progression and suppress dendritic cell-mediated anti-tumor immunity. However, role of β-catenin macrophages its effect on immunity is largely undefined. In this study, using XAV939, a tankyrase inhibitor encapsulated nanoparticles, we explored whether targeting can immunogenicity TME. Our da...

Group 2 innate lymphoid cells (ILC2s), characterized by secretion of type cytokines, regulate multiple immune responses. ILC2s are found in different tumor tissues, and ILC2-derived interleukin (IL)-4, IL-5, IL-13 act on the microenvironment to participate progression. abundant colorectal cancer (CRC) tissue, but role CRC remains unclear. In this study, we that percentage was higher tissue than...

In appendiceal cancers, the most frequently mutated genes are (i) KRAS, which, when reactivated, restores signal transduction via RAS–RAF–MEK–ERK signaling pathway and stimulates cell proliferation in early stages of tumor transformation, then angiogenesis; (ii) TP53, whose inactivation leads to inhibition programmed death; (iii) GNAS, links cAMP pathway, stimulating (iv) SMAD4, exhibiting typi...

UNLABELLED Invasion and metastasis increase after the inhibition of VEGF signaling in some preclinical tumor models. In the present study we asked whether selective VEGF inhibition is sufficient to increase invasion and metastasis and whether selective c-Met inhibition is sufficient to block this effect. Treatment of pancreatic neuroendocrine tumors in RIP-Tag2 mice with a neutralizing anti-VEG...

Angiogenesis is an essential step for tumor survival and progression, and the inhibition of angiogenesis is a good strategy for tumor therapeutics. In this study, we investigated the therapeutic effect of zingerone in a mouse tumor model. Zingerone suppressed tumor progression and tumor angiogenesis. Moreover, we found that zingerone inhibited the angiogenic activities of endothelial cells by b...