نتایج جستجو برای: tubular cell

تعداد نتایج: 1705670  

Journal: :Journal of the American Society of Nephrology : JASN 2013
Kosuke Yamahara Shinji Kume Daisuke Koya Yuki Tanaka Yoshikata Morita Masami Chin-Kanasaki Hisazumi Araki Keiji Isshiki Shin-ichi Araki Masakazu Haneda Taiji Matsusaka Atsunori Kashiwagi Hiroshi Maegawa Takashi Uzu

Obesity is an independent risk factor for renal dysfunction in patients with CKDs, including diabetic nephropathy, but the mechanism underlying this connection remains unclear. Autophagy is an intracellular degradation system that maintains intracellular homeostasis by removing damaged proteins and organelles, and autophagy insufficiency is associated with the pathogenesis of obesity-related di...

Journal: :American journal of physiology. Renal physiology 2013
Song He Na Liu George Bayliss Shougang Zhuang

Proliferation of dedifferentiated intrinsic renal tubular cells has been recognized to be the major cellular event that contributes to renal repair after acute kidney injury (AKI). However, the underlying mechanism that initiates renal tubular dedifferentiation in vivo remains unexplored. Here we investigated whether epidermal growth factor receptor (EGFR) mediates this process in a murine mode...

Journal: :The Journal of clinical investigation 2009
Craig Brooks Qingqing Wei Sung-Gyu Cho Zheng Dong

The mechanism of mitochondrial damage, a key contributor to renal tubular cell death during acute kidney injury, remains largely unknown. Here, we have demonstrated a striking morphological change of mitochondria in experimental models of renal ischemia/reperfusion and cisplatin-induced nephrotoxicity. This change contributed to mitochondrial outer membrane permeabilization, release of apoptoge...

2011
Jinu Kim Jee In Kim Yeon Kyung Na Kwon Moo Park

Renal epithelial cells damaged by ischemia/reperfusion (I/R) can be restored by timely and appropriate treatment. Recent studies have reported that intra renal adult kidney stem cells contribute to the restoration of tubules damaged by I/R. Here, we determined the role of adult tubular cells in the restoration of damaged tubules. We labeled slow cell-cycle cells (SCCs) with 5-bromo-2'-deoxyurid...

2014
Jing Miao Allison M. Lesher Takashi Miwa Sayaka Sato Damodar Gullipalli Wen-Chao Song

The murine cell surface protein Crry (complement receptor 1-related protein/gene y) is a key complement regulator with similar activities to human membrane cofactor protein (MCP) and decay-accelerating factor. MCP has a critical role in preventing complement-mediated tissue injury and its mutation has been implicated in several human kidney diseases. The study of Crry in mice has relevance to u...

Journal: :Journal of the American Society of Nephrology : JASN 2014
Onkar P Kulkarni Ingo Hartter Shrikant R Mulay Jan Hagemann Murthy N Darisipudi Santhosh Kumar Vr Simone Romoli Dana Thomasova Mi Ryu Sebastian Kobold Hans-Joachim Anders

AKI involves early Toll-like receptor (TLR)-driven immunopathology, and resolution of inflammation is needed for rapid regeneration of injured tubule cells. Notably, activation of TLRs also has been implicated in epithelial repair. We hypothesized that TLR signaling drives tubule regeneration after acute injury through the induction of certain ILs. Systematic screening in vitro identified IL-22...

Journal: :British medical journal 1976
A M Cochrane D C Tsantoulos A Moussouros I G McFarlane A L Eddleston R Williams

Sensitisation to a renal tubular antigen, Tamm-Horsfall glycoprotein, has been shown to be common in patients with renal tubular acidosis complicating autoimmune liver disease, and it has been suggested that this immune reaction, by damaging renal tubular cells, might be responsible for the acidification defect. The lymphocytes from 10 out of 13 patients with chronic active hepatitis or primary...

2016
Hanne C. Gadeberg Simon M. Bryant Andrew F. James Clive H. Orchard

In mammalian cardiac ventricular myocytes, Ca efflux via Na/Ca exchange (NCX) occurs predominantly at T tubules. Heart failure is associated with disrupted t-tubular structure, but its effect on t-tubular function is less clear. We therefore investigated t-tubular NCX activity in ventricular myocytes isolated from rat hearts ∼18 wk after coronary artery ligation (CAL) or corresponding sham oper...

1999
JEREMY HUGHES RICHARD J. JOHNSON

Hughes, Jeremy, and Richard J. Johnson. Role of Fas (CD95) in tubulointerstitial disease induced by unilateral ureteric obstruction. Am. J. Physiol. 277 (Renal Physiol. 46): F26–F32, 1999.—Murine renal tubular epithelial cells and interstitial fibroblasts may express both Fas (CD95) death receptor and Fas ligand and are vulnerable to Fas-mediated death in vitro. We therefore hypothesized that a...

Journal: :The Yale Journal of Biology and Medicine 1984
T. Shimamura J. K. Maesaka

Despite significant advances in our understanding or renal tubular cell function, the in vivo handling of E. coli by renal tubules has not been previously investigated. The present studies were, therefore, designed to study this aspect of nephron function. Live and dead E. coli and vehicle alone were microinjected into the proximal tubular lumen of a single nephron of rats, and the microinjecte...

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