Introduction: We have identified numerous examples of anomalous trough stratigraphy within the North Polar Layered Deposits (NPLD). According to the standard model of NPLD stratigraphy [1], troughs can be divided into three main units: (1) Layered Terrain, which exhibit fine-scale laminae upon equatorward-facing (EWF) trough slopes; (2) Banded Terrain, more diffuse layers located on poleward-fa...

When there are insufficient inputs for a product-level approach to requirements elicitation, a process-level perspective is an alternative way for achieving the intended base requirements. We define a V+V process approach that supports the creation of the intended requirements, beginning in a process-level perspective and evolving to a product-level perspective trough successive models derivati...

The quality management in the Municipal Sports Services is embedded in the servuction provided to the citizens, which are their internal customers who determine the quality improvement ensuring competitiveness with excellence criteria. The Model of the European Foundation for Quality Management enables the evaluation of organization progress towards achieving quality goals, from a structured, m...

OBJECTIVES To identify and quantify resource required and associated costs for implementing TNF-α inhibitor (TNFi) drug level and anti-drug antibody (ADAb) tests in UK rheumatology practice. METHODS A microcosting study, assuming the UK National Health Service perspective, identified the direct medical costs associated with providing TNFi drug level and ADAb testing in clinical practice. Reso...

Variability in neonatal vancomycin pharmacokinetics and the lack of consensus for optimal trough concentrations in neonatal intensive care units pose challenges to dosing vancomycin in neonates. Our objective was to determine vancomycin pharmacokinetics in neonates and evaluate dosing regimens to identify whether practical initial recommendations that targeted trough concentrations most commonl...

OBJECTIVE To determine the incidence with which a vancomycin dosing regimen of 15 mg/kg per dose every 6 hours achieves steady-state trough concentrations of 15 to 20 mg/L in pediatric patients with complicated infections. METHODS We performed a retrospective chart review for patients admitted to our children's hospital between July 1, 2009, and June 30, 2011. Patients were included if they w...

introduction zayanderood basin is one of the major internal river basins in the central iran, where zayanderood river is the only permanent river. fluctuations in rainfall in recent years have affected different areas of iran. because of the dependence of the provinces of isfahan, yazd, and kerman on water resources of this basin, changes and fluctuations in precipitation within this watershed ...

The aim of this study was to investigate the association of genetic variants of CYP2C19 (CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles) and voriconazole trough plasma concentrations in Thai patients with invasive fungal infection. A total of 285 samples from patients with invasive fungal infection and treated with voriconazole were prospectively enrolled. At steady state, trough voriconazole conc...

In this paper, we address a set of research questions investigating trends in changes to an open-source system (OSS). An interesting ‘peak and trough’ effect trend was found to exist in the system studied, suggesting that developer activity comprises of a set of high and low periods. Trends in overall changes applied to the system were complemented with empirical evidence in refactoring data fo...