Two new tropane alkaloid N-oxides substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae), a Brazilian indigenous plant, locally known as catuaba and used in traditional medicine as an aphrodisiac. The alkaloid structures were determined by a combination of high resolution mass spectrometry and multi-dimensional NMR spectroscopy.

Family Solanaceae is one of the largest families in plant kingdom. A family 98 genera and over 2700 species; tropical temperate; herbs, shrubs or small trees.
 Secondary metabolites plants, sharing tropane skeleton as a common structural feature, sharply divided into two classes: tropine ecgonine derivatives. The first group, represented by well-known alkaloids: atropine scopolamine, which...

This review describes certain reminiscences about an area of chemical pharmacology I have been involved with, on and off, for many years. Specifically it focuses on tropane, a fascinating, naturally occurring bicyclic chemical ring system that lends itself to many pharmaceutical and therapeutic applications. My involvement with the tropane ring has started more than 60 years ago in 1949, when, ...

in journal: 1. Bálványos, I., László, I., Vida, K., Hank, H., Kursinszki, L., Tóth, E., Sz ke, É.(2001): Effect of magnesium on the genetically modified Atropa belladonna cultures. Magnesium Research 14, 309-310. IF: 0,689 2. Hank H., Bálványos I., Kursinszki L., Tóth E., Sz ke É. (2003): A táptalaj összetételének hatása transzgénikus Atropa belladonna kultúrák alkaloid produkciójára. Gyógyszer...

In the title compound, C(15)H(18)ClNO(2), the inter-nal torsion angles of the tropane ring are comparable to those of tropane rings in the crystal structures reported for cocaine and its derivatives. There is an intra-molecular hydrogen bond between the N atom in the tropane ring and the O atom of the carboxyl group. The crystal structure is further stabilized by many weak C-H⋯O inter-actions b...