TANK-binding kinase 1 (TBK1) plays an essential role in Toll-like receptor (TLR)- and retinoic acid-inducible gene I (RIG-I)-mediated induction of type I interferon (IFN; IFN-α/β) and host antiviral responses. How TBK1 activity is negatively regulated remains largely unknown. We report that TNF receptor-associated factor (TRAF)-interacting protein (TRIP) promotes proteasomal degradation of TBK1...

This study aims to explore the trip fuel consumption from a large-scale dataset. To better understand how the multiple variables (e.g., average travel speed, trip distance) influence the trip fuel consumption, we propose the support vector machine (SVM) to learn the relationship between the trip fuel consumption and the corresponding factors. A large-scale GPS and CAN (Controller Area Network) ...

I/S Nordforbrænding is an inter-municipal waste management company located north of Copenhagen, the capital of Denmark, which serves approximately 180,000 inhabitants. It was founded in 1965 and it is owned by six municipalities in North Sealand: Allerød, Søllerød, Hørsholm, Fredensborg-Humlebæk, Karlebo and Helsingør as shown in Fig. 1. The company’s mission was to establish a Waste-to-Energy ...

One of the most important aims of each treatment planning system is the ability of delivering a target conformal dose distribution. Developed and successful used within the heavy ion therapy pilot project, the TReatment plannIng for Particles ( TRiP )[1] is characterised by the capability of delivering exact results in relatively short time, making it possible to rapidly verify and, if necessar...

INTRODUCTION Providing HIV healthcare and Treatment as Prevention both depend on diagnosing HIV cases, preferably soon after initial infection. We hypothesized that tracing risk networks recruits higher proportions of undiagnosed positives than outreach-based testing or respondent-driven sampling (RDS) in Odessa, Ukraine. METHODS The Transmission Reduction Intervention Project (TRIP) used ris...

Carsharing as a means to provide individuals with access to automobiles to complete a personal trip has grown significantly in recent years in China. However, there are few case studies based on operational data to show the role carsharing systems play in citizens’ daily trips. In this study, vehicle GPS data of a round-trip carsharing system in Hangzhou, China was used to describe the trip cha...

The delay costs of traffic disruptions and congestion and the value of travel time reliability are typically evaluated using single trip scheduling models, which treat the trip in isolation of previous and subsequent trips and activities. In practice, however, when activity scheduling to some extent is flexible, the impact of delay on one trip will depend on the actual and predicted travel time...

TRIP-Br1 oncogenic protein has been shown to have multiple biological functions in cells. In this study, we demonstrate that TRIP-Br1 functions as an oncoprotein by inhibiting autophagy, apoptosis, and necroptosis of cancer cells and eventually helping them to survive under the nutrient/serum starved condition. TRIP-Br1 expression level was significantly increased in conditions with low levels ...

We present a constraint programming formulation for the elevator trip origin-destination matrix estimation problem, and propose different approaches to solve the problem. An elevator trip consists of successive stops in one direction of travel with passengers inside the elevator. It can be defined as a directed network, where the nodes correspond to the stops on the trip, and the arcs to the po...

A new mechanism for the primary photoinduced charge separation in photosynthesis is proposed. It involves as real intermediate between the excited special pair state P * and the primary charge separated state P + H − L a trip-trip-singlet P T B T L , which consists of a triplet on the dimer P and a further triplet on the monomer B L. Both combine to a singlet. The electron transfer is caused by...