Morphine is an effective analgesic in clinical practice; however, its long-term administration causes tolerance, thereby limiting its use. The development of opioid tolerance and its associated hyperalgesia has been associated with interactions between opioid receptors and excitatory amino acids or cytokines. Targeted inhibition of excitatory amino acidand cytokine-mediated signaling pathways m...

the eccentricity connectivity index of a molecular graph g is defined as (g) = av(g)deg(a)ε(a), where ε(a) is defined as the length of a maximal path connecting a to othervertices of g and deg(a) is degree of vertex a. here, we compute this topological index forsome infinite classes of dendrimer graphs.

Hydroxyindoline-derived scaffold, 9, was synthesized with the goal of generating a library of indoline-based natural product-like tricyclic derivatives to be utilized as small-molecule chemical probes. The tricyclic ring was obtained by a Mitsunobu reaction of the N-nosyl amino acid conjugate with the primary hydroxyl group. The solid-phase synthesis was achieved by immobilizing scaffold 9 onto...

ROTH, K. A. AND R. J. KATZ. Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant. NEUROSCI. BIOBEHAV. REV. 5(2) 253-258, 1981.--We have previously shown that rats given stress before open field testing have elevated activity in comparison with unstressed rats. This acute behavioral response may be eliminated by chronic stress and restored by p...

STUDY OBJECTIVE To determine why, despite 122 randomised controlled trials, there is no consensus about whether the selective serotonin reuptake inhibitors or tricyclic and related antidepressants should be used as first line treatment of depression. DESIGN Systematic review of all RCTs comparing selective serotonin reuptake inhibitors and tricyclic or heterocyclic antidepressants. MAIN RES...

A method for the assembly of tricyclic structures containing the peroxide, monoperoxyacetal, and acetal moieties was developed based on the acid-catalyzed reaction of β,δ-triketones with H(2)O(2). Tricyclic compounds are formed selectively in yields from 39% to 90% by the reactions with the use of large amounts of strong acids, such as H(2)SO(4), HClO(4), or HBF(4), which act both as the cataly...

OBJECTIVES To examine the incidence of suicides due to co-proxamol compared with tricyclic antidepressants and paracetamol, and to compare fatality rates for self poisonings with these drugs. DESIGN Analysis of routinely collected national and local data on suicides and self poisonings. SETTING Records of suicides in England and Wales 1997-9; non-fatal self poisonings in Oxford District 199...

The organic anion transporting polypeptide 1A2 (OATP1A2), a membrane drug transporter expressed on important organs (such as the brain, kidney, and intestine) may be a key element in the disposition of drugs. Previous studies demonstrated that it could transport a broad spectrum of substrates, including endogenous molecules and clinically relevant drugs, such as several β-blockers and 3-hydroxy...

solvable graphs (also known as reachable graphs) are types of graphs that any arrangement of a specified number of agents located on the graph’s vertices can be reached from any initial arrangement through agents’ moves along the graph’s edges, while avoiding deadlocks (interceptions). in this paper, the properties of solvable graphs are investigated, and a new concept in multi agent moti...

ackground: The use of antidepressants during pregnancy continues to garner considerable attention, though there are limited nvestigations that have sought to quantify fetal exposure. ethods: Maternal and umbilical cord sera were collected at delivery from ten women taking nortriptyline and seven taking lomipramine. Placental passage was calculated as the ratio of umbilical cord to maternal seru...