al-mcm-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. the reaction was efficiently promoted by 10 mg nano-al-mcm-41 and the heterogeneous catalyst was recycled for four runs in this reaction with...

An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidazole ring was achieved by treatment of α-aminoketones with different aryl or alkyl isothiocyanates. In contrast to previously published synthesis ro...

Tinnitus Research Initiative is dedicated to fi nd a cure for Tinnitus. In this context, we are delighted to present you this fi rst issue of the TRI NEWSLETTER. We hope that this newsletter, will facilitate collaboration and knowledge sharing between supported institutions and interest new stakeholders in order to develop our common network. We would like this newsletter to provide relevant ne...

kaolin-so3h as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. this natural based catalyst is very inexpensive and easy available. imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...

Considerable attention has been devoted recently to the study of conformational changes occurring during enzyme-substrate interaction (1, 2). Presumably the nature of the interaction between apoproteins and their prosthetic groups is essentially similar to that between enzymes and substrates, with the exception that no catalytic step occurs subsequent to the initial binding. Studies of the phys...

A simple highly versatile and efficient sonochemical synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazoles is achieved by condensation of 1,2-dicarbonyl compound, aldehyde, ammonium acetate and primary amine using antimony trichloride immobilized on silica gel (SiO2-OSbCl2) as a catalyst in ethanol at moderate temperature. Operational simplicity, practicability and applicabi...

The three imidazole antimycotics clotrimazole, miconazole, and ketoconazole all inhibit the demethylation of lanosterol to ergosterol, resulting in inhibition of growth of Saccharomyces cerevisiae; this is a fungistatic action. At higher concentrations clotrimazole and miconazole are fungicidal, whereas ketoconazole is not. The fungicidal action reflects direct membrane damage by the imidazoles...

A short and efficient synthesis of 1,4-disubstituted imidazoles has been developed which provides the desired products with complete regioselectivity. This protocol allows preparation of compounds which are challenging to prepare by current literature methods in a regioselective fashion, a sterically and electronically diverse range of N-substituents being accessible. The sequence involves an u...

The electrochemiluminescence (ECL) behavior of pyronin derivatives was reported. We found that these derivatives, as novel ECL emitters, generated an efficient emission phenomenon; is, they showed anodic using tri-propylamine (TPA) the coreactant and cathodic K 2 S O 8 coreactant. Because its remarkable luminescent performance, mechanism (reductive-oxidative oxidative-reductive) benzylthiol-sub...