In the last decade, a plethora of studies utilizing pharmacological, biochemical, and genetic approaches have shown that precise translational control is required for long-lasting synaptic plasticity and the formation of long-term memory. Moreover, more recent studies indicate that alterations in translational control are a common pathophysiological feature of human neurological disorders, incl...

exosomes, as a mediator of cell-to-cell transfer of genetic information, act an important role in intercommunication between tumor cells and their niche including fibroblasts, endothelial cells, adipocytes and monocytes. several studies have shown that tumor cells can influence their neighboring cells by releasing exosomes. these exosomes provide signaling cues for stimulation, activation, prol...

We propose a second-order multi-agent system for target tracking on sphere that contains centripetal force, bonding velocity alignment operator to the target, and cooperative control terms between flocking agents. employ regularized rotation instead of Rodrigues’ derive tracking. From property operator, we can decompose phase agents into translational structural parts. By analyzing part this re...

The physiological importance of translational regulation in controlling the synthesis of ribosomal proteins from the L11 ribosomal protein operon was determined for the classical regulatory phenomena of growth rate dependence and stringent control. Translational regulation of the L11 operon by ribosomal protein L1, the L11 operon-specific translational repressor protein, was abolished by introd...

The present article reports a study carried out to investigate whether or not awareness of functional translation theories has any impact on the translation quality of translator trainees. 2oo Iranian undergraduate students took part in this study. They were divided into four groups -two- experimental and two control groups. After homogenizing the participants by a TOEFL test, a translation pre...

in this paper, exact solution for two-plane transverse vibration analysis of axial-loaded multi-step timoshenko rotor carrying concentrated masses is presented. each attached element is considered to have both translational and rotational inertia. forward and backward frequencies and corresponding modes are obtained using transfer matrix method (tmm). the effect of the angular velocity of spin,...

The synthesis and destruction of cyclin B drives mitosis in eukaryotic cells. Cell cycle progression is also regulated at the level of cyclin B translation. In cycling extracts from Xenopus embryos, progression into M phase requires the polyadenylation-induced translation of cyclin B1 mRNA. Polyadenylation is mediated by the phosphorylation of CPEB by Aurora, a kinase whose activity oscillates ...

Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory ne...

Translation initiation is generally the rate limiting step Over twenty years ago, an obligatory role for protein in the overall process and is influenced by elements translation in G1 cell cycle progression was brought to within the 59 untranslated region (UTR) of the mRNA. light (reviewed by Norbury and Nurse, 1992). Transit The rapamycin-sensitive translation of an IGF-II mRNA through the cel...

In the past decade, translational control has been shown to be crucial in the regulation of gene expression. Research in this field has progressed rapidly, revealing new control mechanisms and adding constantly to the list of translationally regulated genes. There is accumulating evidence that translational control plays a primary role in cell-cycle progression and cell differentiation, as well...