Recent advances in optical technology have taken fluorescent imaging beyond the standard two-dimensional (2D) epifluorescence imaging into the realm of three-dimensional (3D) fluorescence molecular tomographic (FMT®) imaging for improved localization and quantification in deep tissue. This requires the transillumination of animals (i.e. the passing of light through the animals) rather than the ...

We have investigated the problem of edge effects in laser-beam transillumination scanning of the human breast. Edge effects arise from tissue thickness variability along the scanned area, and from lateral photon losses through the sides of the breast. Edge effects can be effectively corrected in frequency-domain measurements by employing a two-step procedure: (1) use of the phase information to...

The applicability and limits of time-resolved transillumination to determine the internal details of biological tissues are investigated by phantom experiments. By means of line scans across a sharp edge, the spatial resolution (Δx) and its dependence on the time-gate width (Δt) can be determined. Additionally, measurements of completely absorbing bead pairs embedded in a turbid medium demonstr...

BACKGROUND A new technique for visualisation of the vitreous base is described. It uses a standard lightpipe for scleral indentation and transillumination. Visualisation of the vitreous using low light levels can be achieved by enhancing the Tyndall effect. DISCUSSION Perfluorocarbon liquid (PFCL) is used to confine the aqueous environment to the anterior vitreous cavity and triamcinolone is ...

The absence of non-destructive inspection techniques for illicit drugs hidden in mail envelopes has resulted in such drugs being smuggled across international borders freely. We have developed a novel basic technology for terahertz imaging, which allows detection and identification of drugs concealed in envelopes, by introducing the component spatial pattern analysis. The spatial distributions ...