نتایج جستجو برای: transgelin

تعداد نتایج: 164  

2016
Jason P. Webber Lisa K. Spary Malcolm D. Mason Zsuzsanna Tabi Ian A. Brewis Aled Clayton

Changes within interstitial stromal compartments often accompany carcinogenesis, and this is true of prostate cancer. Typically, the tissue becomes populated by myofibroblasts that can promote progression. Not all myofibroblasts exhibit the same negative influence, however, and identifying the aggressive form of myofibroblast may provide useful information at diagnosis. A means of molecularly d...

Journal: :Circulation 2013
Domenick A Prosdocimo Rajan Jain Mukesh K Jain

C ellular plasticity has become the subject of intense research, with perhaps the greatest example provided by the recent Nobel Prize winners Drs Yamananka and Gurdon and the demonstration that terminally differentiated fibro-blasts can be coaxed into assuming an embryonic stem cell-like fate. Emerging evidence suggests that plasticity inherent in cells may be hijacked in the progression of dis...

Journal: :The Journal of Cell Biology 2004
Karen Birmingham

n page 803, Gourlay et al. report the first evidence that the actin cytoskeleton can affect release of reactive oxygen species (ROS) by mitochondria, and thus life span in yeast. Certain mutant Saccharo-myces cerevisiae strains with alleles that reduce actin dynamics possess defective mitochondria. The team O Cells with increased actin dynamics live longer. went on to show that such strains dis...

2010
Emma C Derrett-Smith Audrey Dooley Korsa Khan Xu Shi-wen David Abraham Christopher P Denton

INTRODUCTION Vasculopathy, including altered vasoreactivity and abnormal large vessel biomechanics, is a hallmark of systemic sclerosis (SSc). However, the pathogenic link with other aspects of the disease is less clear. To assess the potential role of transforming growth factor beta (TGF-beta) overactivity in driving these cardiovascular abnormalities, we studied a novel transgenic mouse model...

2016
Rokas Navickas Diane Gal Aleksandras Laucevičius Agnė Taparauskaitė Monika Zdanytė Paul Holvoet

The aim of the present study is to identify microRNAs (miRs) with high potential to be used as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis for survival in, patients with atherosclerosis, coronary artery disease, and acute coronary syndrome (ACS). A systematic search of published original research yielded a total of 72 studies. After review of the risk...

2008
Nesrine El-Bizri Christophe Guignabert Lingli Wang Alexander Cheng Kryn Stankunas Ching-Pin Chang Yuji Mishina Marlene Rabinovitch

INTRODUCTION Bone morphogenetic protein receptors (BMPRs) are members of the transforming growth factor β superfamily of receptors (de Caestecker, 2004; Mehra and Wrana, 2002). Heteromeric complexes form between BMPR1 and BMPR2 (Gilboa et al., 2000). Aberrant BMP signaling has been linked to pulmonary arterial hypertension (PAH). Various germline mutations in BMPR2 have been identified in famil...

Journal: :The Journal of Cell Biology 2004
Karen Birmingham

n page 803, Gourlay et al. report the first evidence that the actin cytoskeleton can affect release of reactive oxygen species (ROS) by mitochondria, and thus life span in yeast. Certain mutant Saccharo-myces cerevisiae strains with alleles that reduce actin dynamics possess defective mitochondria. The team O Cells with increased actin dynamics live longer. went on to show that such strains dis...

Journal: :The Journal of Cell Biology 2004
Karen Birmingham

n page 803, Gourlay et al. report the first evidence that the actin cytoskeleton can affect release of reactive oxygen species (ROS) by mitochondria, and thus life span in yeast. Certain mutant Saccharo-myces cerevisiae strains with alleles that reduce actin dynamics possess defective mitochondria. The team O Cells with increased actin dynamics live longer. went on to show that such strains dis...

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