Symbiodinolide is a polyol marine natural product with a molecular weight of 2860. Herein, a streamlined synthesis of the C79-C97 fragment of symbiodinolide is described. In the synthetic route, a spiroacetalization, a Julia-Kocienski olefination, and a Sharpless asymmetric dihydroxylation were utilized as the key transformations.

Alkoxyallenes are unusually versatile C3 building blocks in organic synthesis. Hence this tutorial review summarizes the most important transformations, including subsequent reactions and their applications in the synthesis of relevant compounds, e.g. natural products. The reactivity patterns involved and the synthons derived from alkoxyallenes are presented. Often alkoxyallenes can serve as su...

Over the past decade, ruthenium-mediated metathesis transformations, including cross-metathesis, ring-closing metathesis, enyne metathesis, ring-opening metathesis polymerization, and also tandem processes, belong to the most intensively studied reactions. Many applications of olefin metathesis in the synthesis of natural products have been recently described. Also in the field of steroid chemi...

Nitrogen heteroarenes form an important class of compounds which can be found in natural products, synthetic drugs, building blocks etc. Among the diverse strategies that were developed for the synthesis of nitrogen heterocycles, oxidative dehydrogenation is extremely effective. This review discusses various oxidative dehydrogenation strategies of C-C and C-N bonds to generate nitrogen heteroar...

Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these compounds, enantioenriched 3-hydroxyoxindole scaffolds also exist in natural products and have proven to possess promising biological activiti...

Supply chain management is about improving the products, processes and functioning of the chain of enterprises involved in the delivery of products and services from raw materials. This paper provides a brief review of supply chain management and reviews some supply chain transformation methodologies. A standard methodology that guides in the transformation of the supply chain is presented. Als...

Unsaturated spirocyclic substrates bearing two alkenyl chains underwent ruthenium-mediated ring-rearrangement metathesis through relaying cyclohexene and cycloheptene moieties to give angularly fused tricyclics. In some instances where two products were expected, high degrees of selectivity were observed. In one instance the structural parameter leading to selectivity was very subtle; in others...

Datalog systems evaluate joins over arithmetic (in)equalities as a naive generate-and-test of Cartesian products. We exploit aggregates in a source-to-source transformation to reduce the size of Cartesian products and to improve performance. Our approach approximates the well-known propagation technique from Constraint Programming. Experimental evaluation shows good run time speed-ups on a rang...

Overall persistence (POV) and long-range transport potential (LRTP) of and endosulfan and two of their transformation products, endosulfan sulfate and endosulfan diol, are estimated with two multimedia box models, the OECD POV and LRTP Screening Tool and the global, latitudinally resolved model CliMoChem. The OECD Tool yields POV and LRTP for each compound separately, whereas the CliMoChem mode...

The financial transformation journey is often addressed through trying to avoid the pitfalls associated with the causes of failure while leveraging the critical success factors. At best, Chief Financial Officers adopting this approach are likely to improve the degree of customer service experienced by Finance department. This is unlikely to lead to sustainable financial transformation being ach...