glutathione s-transferase (gst) is a superfamily enzyme which plays a major role indetoxification of xenobiotic compounds by catalyzing the conjugation of xenobiotic to cellular glutathione(gsh). gst-p is an important class of gsts which is expressed during the early stage of life and duringdevelopmental stages. its activity is relatively high during embryogenesis and immediately after birth an...

Human glutathione S-transferase pi (GST-pi) may serve as a useful tumor marker because of the high frequency with which it is found in elevated levels in several tumor types. To determine whether GST-pi is useful as an indicator for cancers of the head and neck, expression of GST-pi mRNA was investigated by Northern analysis in this tumor type. Overexpression of GST-pi mRNA was detected in 9 of...

GST-TAT-SOD was the fusion of superoxide dismutase (SOD), cell-permeable peptide TAT, and glutathione-S-transferase (GST). It was proved to be a potential selective radioprotector in vitro in our previous work. This study evaluated the in vivo radioprotective activity of GST-TAT-SOD against whole-body irradiation. We demonstrated that intraperitoneal injection of 0.5 ml GST-TAT-SOD (2 kU/ml) 2 ...

Herpes simplex virus 1 (HSV-1) unspliced 8.3 latency associated transcript (LAT), which located in the long repeat sequences, has been shown to contain at least 16 open reading frames (ORF: A-P). One of these ORF, ORF P, maps almost entirely antisense to HSV-1 neurovirulence gene, ICP34.5. Both ORF P and ICP34.5 are located in the long repeat and are antisense overlapping genes. Therefore, in O...

he objective of the present study was to evaluate the effect of abamectin on liver function of rats. Abamectin is used as antiparasitic drug in agricultural and domestic animals. Sixty adult male albino rats (150±10g) were classified into 3 groups: Group (1), Control group given tap water; Group (II) Sub-acute group orally treated with 2 /3 LD50 of abamectin (9.83 mg/kg b.w) for 21 days (4 dose...

High glutathione S-transferase (GST) activity may contribute to colorectal cancer prevention. Functional polymorphisms are known in the GSTM1, GSTT1, GSTA1 and GSTP1 genes. The influence of these GST polymorphisms and recent fruit and vegetable consumption on GST levels and activity has not been investigated simultaneously in a human population. Also, it is not clear if blood GST activity refle...

Background: Lead is a highly toxic metal of great public health importance. Objectives: This cross-sectional study was conducted to evaluate the kidney and liver function status markers oxidative stress among lead recycling factory workers in Anambra State, Nigeria. Methods: A total 82 subjects (41 experimental 41 control subjects) aged 20-60 years were recruited this study. levels whole blood ...

AMP-activated protein kinase (AMPK) is a cellular and whole body energy sensor with manifold functions in regulating energy homeostasis, cell morphology and proliferation in health and disease. Here we apply multiple, complementary in vitro and in vivo interaction assays to identify several isoforms of glutathione S-transferase (GST) as direct AMPK binding partners: Pi-family member rat GSTP1 a...

Pollution by heavy metals is a serious problem due to their toxicity and ability to accumulate in the biota. In vivo effects of Cadmium (Cd) levels of expression on antioxidant enzymes such as Catalase (CAT) and Glutathione-S-transferase (GST) were investigated in liver, kidney, gill and brain tissues of freshwater Catfish, Clarias gariepinus. CAT is a common antioxidant enzyme which breaks dow...