a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...

We present an approach for the visual analysis of multi-omics data obtained using high-throughput methods. The term “omics” denotes measurements different types biologically relevant molecules like products gene transcription (transcriptomics) or abundance proteins (proteomics). Current popular visualization approaches often only support analyzing each these omics separately. This, however, dis...

Brugada syndrome (BrS) is an inherited disorder that can lead to sudden cardiac death. Candidate genes primarily include those encoding the sodium channel, whereas other genetic variants affecting channels, signaling, scaffold, sarcomere, and mitochondrial proteins are controversial, leaving architecture of BrS largely unknown. The aim this work was improve diagnosis prognosis BrS, further unde...

The popularization of genomic high-throughput technologies is causing a revolution in biomedical research and, particularly, is transforming the field of drug discovery. Systems biology offers a framework to understand the extensive human genetic heterogeneity revealed by genomic sequencing in the context of the network of functional, regulatory and physical protein-drug interactions. Thus, app...

The ability to measure the transcriptomes of single cells has only been feasible for a few years, and is becoming an extremely popular assay. While many types of analysis and questions can be answered using single cell RNA-sequencing, a central focus is the ability to survey the diversity of cell types within a sample. Unbiased and reproducible cataloging of distinct cell types requires large n...

Obesity is an ever-growing epidemic where tissue homeostasis is influenced by the differentiation of adipocytes that function in lipid metabolism, endocrine and inflammatory processes. While this differentiation process has been well-characterized in mice, limited data is available from human cells. Applying microarray expression profiling in the human SGBS pre-adipocyte cell line, we identifie...