The anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl-2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated controlgroup (C) (n=6), I/R group (...

A 56-year-old woman was admitted because of frequent watery diarrhea, vomiting, and abdominal cramps. An examination of the stool for norovirus antigen was positive, and a blood examination revealed a marked elevation of liver enzymes. Liver dysfunction, as well as symptoms related to gastroenteritis, was ameliorated solely by supportive treatment. Although liver injury concurrent with noroviru...

We determined transaminases in human blood serum with an amperometric glutamate biosensor. The probe was a hydrogen peroxide sensor assembled with appropriate selective membranes to enhance the probe specificity and lifetime. Calibration curves of glutamate were linear in the range 1-1000 mumol/L, with a response time of < 1 min. This probe was subsequently applied to the measurement of activit...

Case presentation: To describe the outcome of clinical evolution two SMA patients with positive test for AAV9 antibody, treated gene therapy. report: Patient 1, C.M.M., currently 2 years and 11 months, was diagnosed spinal muscular atrophy type C at 7 months due to loss cervical tonus reduction lower limbs movement, associated weight caused by dysphagia, initiation Spinraza treatment 10 months....

Introduction: Viral hepatitis B is a major public health problem worldwide. The aim of this study was to evaluate the clinico-biological parameters in patients with chronic on Tenofovir. Patients and method: This cross-sectional retrospective data collection from April 1, 2019 March 31, 2021, i.e. two years. aged at least 15 years, regardless sex, complete follow-up file were included. Results:...

Background : Corona virus 2019 (COVID-19) is an infectious viral disease caused by SARS-CoV-2 that has infected the world. COVID-19 can cause abnormalities which are characterized increased levels of enzyme transaminase and bilirubin. Research on association between enzymes bilirubin still limited, further research needed degree transaminases enzymes. Aim: To determine liver function severity o...

Abstract: Tocilizumab is an anti-IL-6 which recommended as cytokine release syndrome therapy in the treatment of Covid-19. One side effects tocilizumab that can occur hepatotoxicity, from mild elevated transaminases to severe drug-induced liver injury (DILI). Currently, research related hepatotoxicity and risk factors affecting Covid-19 patients limited still needs conduct. This observational s...