7-Fluorobenz(a)anthracene (7-FBA) was metabolized by rat liver microsomes predominantly to 4-hydroxy-7-FBA and 7-FBA trans-3,4-, 5,6-, 8,9-, and 10,11-dihydrodiols. Proton nuclear magnetic resonance spectral analyses indicated that the fluoro substituent causes 7-FBA trans-5,6- and 8,9-dihydrodiols to adopt preferentially quasidiaxial conformations (Chiu, P.-L., Fu, P. P., and Yang, S. K. Bioch...

Trans fatty acids are found mainly in processed foods. It has been shown that when their intake is high, total cholesterol, LDL-cholesterol and triacylglycerols are elevated, while HDL-cholesterol decreases. To evaluate a possible effect of these compounds, even in low amounts, C57Bl/6J mice were fed for 7 weeks a diet containing 13.6 % energy as partially hydrogenated rapeseed oil-enriched die...

Three 2D and 3D photoreactive MOFs of trans,trans-muconic acid with Er(3+) and their corresponding isomorphous Y(3+) phases were synthesized and their photoreactivity was studied as a function of the crystal environment.

A series of octahedral ruthenium silyl hydride complexes, cis-(PMe(3))(4)Ru(SiR(3))H (SiR(3) = SiMe(3), 1a; SiMe(2)CH(2)SiMe(3), 1b; SiEt(3), 1c; SiMe(2)H, 1d), has been synthesized by the reaction of hydrosilanes with (PMe(3))(3)Ru(eta(2)-CH(2)PMe(2))H (5), cis-(PMe(3))(4)RuMe(2) (6), or (PMe(3))(4)RuH(2) (9). Reaction with 6 proceeds via an intermediate product, cis-(PMe(3))(4)Ru(SiR(3))Me (S...

The platinum butadiynyl complex trans-(C(6)F(5))(p-tol(3)P)(2)Pt(C≡C)(2)H and a CuI adduct of a 1,10-phenanthroline based 33-membered macrocycle react in the presence of K(2)CO(3) and I(2) or O(2) to give a rotaxane (ca. 9%) in which the macrocycle is threaded by the sp carbon chain of trans,trans-(C(6)F(5))(p-tol(3)P)(2)Pt(C≡C)(4)Pt(Pp-tol(3))(2)(C(6)F(5)). The crystal structure and macrocycle...

A diphosphine ligand (1·HPF(6)), which is a potential precursor to a PC(NHC)P pincer, with a backbone containing two phenylene groups and a central bicyclic 4-aza-2-azoniabicyclo[3.2.1]oct-2-ene unit has been synthesised and coordinated to Pd(II) and Pt(II) to give trans-[M(κ(2)-P,P'-)Cl(2)]PF(6) where M = Pd (2) or Pt (3a). Single-crystal structure determinations of 2 and 3a show the complexes...

Laboratory experiments were conducted to determine the mineralization rates of 1,3-dichloropropene (1,3-D) in surface and subsurface soil samples collected from three sites in Florida with different histories of 1,3-D exposure. Mineralization rates of uniformly labeled (1)C-1,3-D in surface and subsurface samples collected from two of the three sites, one of which was treated with 1,3-D only on...

The ruthenium NO donors of the group trans-[Ru(NO)(NH3)4L]n+, where the ligand (L) is N-heterocyclic H2O, SO(3)(2-), or triethyl phosphite, are able to lyse Trypanosoma cruzi in vitro and in vivo. Using half-maximal (50%) inhibitory concentrations against bloodstream trypomastigotes (IC50try) and cytotoxicity data on mammalian V-79 cells (IC50V79), the in vitro therapeutic indices (TIs) (IC50V7...

Nectins, Ca(2+)-independent immunoglobulin (Ig)-like cell-cell adhesion molecules and cadherins, Ca(2+)-dependent cell-cell adhesion molecules, are associated through their respective cytoplasmic tail-binding proteins, afadin and catenins and play roles in formation of adherens junctions (AJs) in epithelial cells and fibroblasts. Nectin-like molecule-5 (Necl-5) is a Ca(2+)-independent Ig-like m...