background: recently, tissue engineering has developed approaches for repair and restoration of damaged skeletal system based on different scaffolds and cells. this study evaluated the ability of differentiated osteoblasts from adipose‑derived stem cells (adscs) seeded into hydroxyapatite/ tricalcium phosphate (ha‑tcp) to repair bone. methods: in this study, adscs of 6 canines were seeded in ha...

We have studied the effect of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) on the morphology of rat bone and the metastatic behavior of Walker 256 (W256) cancer cells in the rat skeleton. Male Fischer rats (150-175 g) received s.c. injections for 7 days with APD (0.5 mg/kg body weight/day) (+ APD; n = 20) or with vehicle (-APD; n = 20). Subsequently, 10 + PD and 10 -APD rats received i...

A clear understanding of the dependence of mechanical properties of bone remains a task not fully achieved. In order to estimate the mechanical properties in bones for implants, pore cross-section area, calcium content, and apparent density were measured in trabecular bone samples for human implants. Samples of fresh and defatted bone tissue, extracted from one year old bovines, were cut in lon...

INTRODUCTION Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. The aim of the present study was to evaluate the architecture of subchondral bone in regions with and without BMLs from the same individual using bone histomorphometry. METHODS Postmenop...

Trabecular bone holds the utmost importance due to its significance regarding early loss. Diseases like osteoporosis greatly affect structure of which results in different outcomes high risk fracture. The objective this paper is inspect characteristics Bone by using Magnetic Resonance Imaging (MRI) technique. These prove be quite helpful studying studies related such as osteoporosis. things tha...

Osteoporosis and osteoarthritis (OA) are two common age-related skeletal disorders, which are associated with substantial morbidity and disability, particularly among elderly women. The present study was performed to investigate the trabecular bone deterioration of proximal tibiae and lumbar vertebrae in postmenopausal women with OA. The results demonstrated that the histomorphometric section o...

Disuse typically causes an imbalance in bone formation and bone resorption, leading to losses of cortical and trabecular bone. In contrast, bears maintain balanced intracortical remodeling and prevent cortical bone loss during disuse (hibernation). Trabecular bone, however, is more detrimentally affected than cortical bone in other animal models of disuse. Here we investigated the effects of hi...

Limb elements in birds have been characterized as exhibiting a reduction in trabecular bone, thinner cortices and decreased bending strength when pneumatized, yet it is unclear if these characteristics generalize to the axial skeleton. Thin section techniques, the traditional gold standard for bone structure studies, have most commonly been applied to the study of avian bone. This destructive t...

Objetivo: Analizar la utilidad del trabecular bone score (TBS) en adultos con osteogénesis imperfecta (OI) y su relación variables clínicas, antropométricas densitométricas, especialmente presencia de fracturas severidad enfermedad.

A three-dimensional simulation of trabecular surface remodeling was performed to investigate the basic effects of a fixation screw on the trabecular structural changes in a vertebral body. Voxel-based finite elements were used to construct computational models of the bone and screw for an entire vertebral body with the screw and for the bone-screw interface. The remodeling simulation for the en...