Nineteen mycophenolic acid (MPA) derivatives were designed and synthesized, their anti-Toxoplasma activity evaluated for the first time. Among them, N-propylimidazole-modified compound E5 demonstrated strongest activity, IC50 against HFF-1 (Human Foreskin Fibroblasts-1) cells following infection with T. gondii is 80.9 μM (MPA-211.5 μM) its selectivity index 2.2 (MPA-1.2). In vivo experiments, c...

introduction toxoplasma gondii is one of the most important pathogen that has adverse effect on reproductive function. evidence acquisition recent studies revealed that infection with t. gondii not only affect female reproduction, also cause male reproductive impairment. in clinical studies, high prevalence of toxoplasmosis in sterile men has been reported. in animal models, toxoplasmosis is as...

background: to study toxoplasmosis in neonates using pcr and serological methods. methods: sera and csf of 104 neonates, hospitalized in infants' ward of taleghani hospital, tehran, iran were examined. the sera were examined for anti toxoplasma gondii lgm and lgg specific antibodies with elisa and ifa techniques, respectively. meanwhile, obtained csfs of the cases were evaluated for the genome ...

BACKGROUND Toxoplasmosis is a relatively common cause of infectious papillitis and neuroretinitis, which may affect both immunocompetent immunodeficient patients. CASE PRESENTATION A previously healthy woman in her mid-forties presented with subacute onset unilateral blurry vision retrobulbar pain exacerbated by eye movements. Ophthalmological assessment revealed decimal best-corrected visual a...

background: the aim of this study was to determine the toxoplasma antibodies in pregnant women in zanjan, by elisa method. methods: blood samples were taken from 500 pregnant women referred to the health centers of zanjan city, north west iran, igm and igg titers were primarily evaluated. the collected data were analyzed with spss 11.5 using chi-square test. results: anti toxoplasma igm and igg...

toxoplasmosis is a widespread infection in the world. although the infection by toxoplasma gondii is widely prevalent in humans and animals, the disease is uncommon and most of the acquired infections are asymptomatic. the important aspect of this parasitic infection is the probable danger of congenital transmission and its severe effects on the fetus. in the present descriptive study, a total ...

The limitations of serological assessment in toxoplasma infection of the eye are well recognised, but the predictive value of clinical examination is not defined. We undertook a prospective investigation into the role of clinical examination and of serological findings in cases of suspected toxoplasma infection of the eye by means of the dye test and multiple IgM assays. Seventy-four cases of r...

Background: Human toxoplasmosis is an important zoonotic infection worldwide which is caused by the intracellular parasite Toxoplasma gondii (T.gondii). The aim of this study was to review briefly the general aspects of toxoplasma infection in   in Iranian health system network. Methods: We searched published toxoplasmosis related articles in English databases including Science Dir...

Intracellular Toxoplasma gondii grown in human foreskin fibroblast cells transported nitrobenzylthioinosine [NBMPR; 6-[(4-nitrobenzyl)mercapto]-9-beta-D-ribofuranosylpurine], an inhibitor of nucleoside transport in mammalian cells, as well as the nonphysiological beta-L-enantiomers of purine nucleosides, beta-L-adenosine, beta-L-deoxyadenosine, and beta-L-guanosine. The beta-L-pyrimidine nucleo...