The Cry48Aa/Cry49Aa binary toxin of Bacillus sphaericus was recently discovered by its ability to kill Culex quinquefasciatus mosquito larvae through a novel interaction between its two components. We have investigated the target specificity of this toxin and show it to be non-toxic to coleopteran, lepidopteran and other dipteran insects, including closely related Aedes and Anopheles mosquitoes...

Harmful algal blooms (HABs), varying in intensity and causative species, have historically occurred throughout the Chesapeake Bay, U.S.; however, phycotoxin data are sparse. The spatiotemporal distribution of phycotoxins was investigated using solid-phase adsorption toxin tracking (SPATT) across 12 shallow, nearshore sites within lower Bay Virginia's coastal bays over one year (2017-2018). Eigh...

In 2008, an unusual strain of methicillin-sensitive Staphylococcus aureus (MSSA68111), producing both Panton-Valentine leukocidin (PVL) and toxic shock syndrome toxin-1 (TSST-1), was isolated from a fatal case of necrotizing pneumonia. Because PVL/TSST-1 co-production in S. aureus is rare, we characterized the molecular organization of these toxin genes in strain 68111. MSSA68111 carries the PV...

DNA encoding ricin B chain was derived from preproricin genomic DNA and ligated into the baculovirus transfer vector, pAcGP67A. Co-transfection of Spodoptera frugiperda Sf9 cells with BaculoGold DNA was followed by limiting dilution purification of recombinant baculovirus. Infection of SF9 cells at a multiplicity of infection of 1 in the presence of 25 mM lactose produced 3 mg/l of soluble, gly...

Background: Use of botulinum toxin is becoming a popular way in treatment of some forms of strabismus.To evaluate the morphological changes in the orbital surface layer muscles of the rabbit eye following a single injection of botulinum toxin. Methods: 10 white Dutch rabbits weighing 2–3 kg received either 10 units (group 1; n=5) or 20 units (group 2; n=5) of botulinum toxin into the superior r...

Introduction and aim of the study: Botulinum toxin, produced by anaerobic bacteria Clostridium botulinum family, is one most potent organic compounds known to man. Despite its toxicity, it has found widespread use in medicine. From applications aesthetic medicine, through treatment various disease entities, toxin become an extremely valuable tool hands doctors. The this study review latest rese...

The newest emerging viral infection of dogs is canine circovirus. It was thought to be the cause of illness and mortality in Ohio dogs in late August/early September 2013. Canine circovirus can either be the primary infection or present in the form of co-infection with other enteric pathogens. Its role as a primary pathogen still needs to be defined. In a recent paper, Linlin et al (1) document...

background: the mesobuthus eupeus scorpion venoms are known to contain α-toxin peptides, many of which interfere with k+ ion channel function. these toxin peptides have important value in  the pharmacology and physiology studies of specific k+ channel of cells. objectives: given the  lack of information of the molecular biology of peptides in the toxin of iranian scorpions, the aim of this stud...

t-2 toxin, a trichothecene mycotoxin, is considered to be one of the most toxic compounds that are produced by molds, particularly the fusarium species. fusarium species have been recognized as a great agricultural problem. they occur worldwide on a variety of plant hosts and cereal grains. the aim of this study was to investigate t-2 toxin-induced liver injury using in situ perfused rat liver....

PURPOSE We investigated the effectiveness and safety of intravesical resiniferatoxin (Sigma Chemical Co., St. Louis, Missouri) and botulinum-A toxin injections into the detrusor muscle in a group of spinal cord injured patients with neurogenic detrusor overactivity unresponsive to conventional anticholinergic therapy. MATERIALS AND METHODS A total of 25 patients were randomly assigned to rece...