This article reviews the mechanistic basis of the tissue residue approach for toxicity assessment (TRA). The tissue residue approach implies that whole-body or organ concentrations (residues) are a better dose metric for describing toxicity to aquatic organisms than is the aqueous concentration typically used in the external medium. Although the benefit of internal concentrations as dose metric...

Trichloroethylene (TCE) and perchloroethylene or tetrachloroethylene (PCE) are high-production volume chemicals with numerous industrial applications. As a consequence of their widespread use, these chemicals are ubiquitous environmental contaminants to which the general population is commonly exposed. It is widely assumed that TCE and PCE are toxicologically similar; both are simple olefins wi...

Deoxynivalenol (DON) is detected in different types of foods and feeds, inducing toxicity humans animals. After entering the organism, DON first appears plasma; then, it rapidly absorbed distributed various organs tends to accumulate body exert its toxic effects. This study was performed investigate toxicokinetics on Dezhou male donkeys after a single oral dose 500 μg/kg·BW (body weight). The p...