Background and Aims: Although metal and metal oxide nanoparticles are used in different medical applications, they may have considerable toxicity on various cells, such as myocytes. Therefore, this study aimed to evaluate the toxicity of the naked and serum-treated silver nanoparticles (Ag NPs) and magnesium oxide nanoparticles (MgO NPs) on the cardiomyocytes. Materials and Methods: Cardiomy...

objective: chlorpyrifos (cpf) is a neurotoxic organophosphorus (op) insecticide. its mechanism of action includes oxidative stress, excitotoxicity, and inhibition of the acetylcholinesterase enzyme (ache). the aim of the present study is to investigate cpf toxicity in mature and immature cerebellar granule neurons (cgns), as well as its effect on glutamate induced excitotoxicity. materials and ...

background: the alcoholic decoction of root ethanolic extract of aristolochia ringens is taken orally to treat various ailments in south-west nigeria without prior knowledge of its potential toxic effect. therefore, this study aimed at assessing the toxicity potentials of root ethanolic extract of a. ringens on functional indices and histology of the liver. methods: twenty male rats were random...

the effect of fungicides on silkworm larvae was analyzed with regard to the fact that these beneficial insects are usually affected by fungicides, daily feeding on 1 and 2g/liter of carbendazim, a systemic fungicide, did not have significant effects on larval and pupal mortality. however the weight of the treated larvae showed considerable weight decrease up to 37% weight.. all the economic tra...

antibiotic resistance to microorganisms is one of the major problems faced in the field of wound care in burns patients. silver nanoparticles have come up as potent antimicrobial agent and are being evaluated in diverse medical applications ranging from silver based dressings to silver coated medical devices. we aimed in present study to test the release of nanosilver from nanosilver wound dres...

the mechanism by which lead may cause a perturbotion in the nevous system is through the nitric oxide synthase. in this study the effect of lead acetate on the hippocampal constitutive nitric oxide production was studied. the variation in the nitric oxide production may contribute to physiological lead neurotoxicity in vivo. different concentrations of lead acetate (10-9 to 10-6 m), wre added t...

quantum dots are new types of fluorescent materials for biological labeling. as a result, qds toxicity study is an essential requirement for future clinical applications. therefore, the cytotoxic cdse:zns quantum dots effects on some organs in mice are presented in this study. in this work, 10, 20 and 40 mg/kg doses of cdse:zns quantum dots were injected to 32 adult male mice. structural and op...

background: in this study, the protective effect of thymoquinone (tq) and nigella sativa seeds oil (nso) was evaluated against oxidative damages induced by ethanol in rats. methods: animals were treated with ethanol 40% daily by gavages once a day for 4 weeks. nso and tq were injected intraperitoneal once a day for 4 weeks. the histopathological examination of liver, kidney, brain and heart was...

aluminum oxide nanoparticles are the most widely used nanoparticles in various industries.theincreasing use of nanoparticles in the past two decades and their entry into the industrial and non-industrialwaste water necessitates the assessment of potential effects of these substances in aquatic ecosystems. oecdstandard method was applied to determine the toxicity of this substance. after perform...

histopathology on the olfactory organ of a snakehead fish, channa punctatus (bloch, 1793) were assessed after exposing the fish to 2.5 mg/l and 5mg/l of cdcl 2 for 15 days, 30 days and 45 days. cellular organization of the epithelium was affected severely with degeneration of sensory and supporting cells and hyperplasia of basal cells and mucous cells. mucous cell proliferation indicates the up...