this study represents the first report on the chemical composition and biological activity of trifolium angustifolium var. angustifolium. the major components of the essential oil were identified as hexatriacontene (23.0%), arachidic acid (15.5%) and α-selinene (10.0%). the main constituents of the fatty acid obtained from the petroleum ether extract were identified as palmitic acid (29.8%), li...

The active component of the acne drug Accutane is 13-cis-retinoic acid (RA), and it is highly teratogenic for the developing central nervous system. Very little is known, however, regarding the effect of this drug on the adult brain. Regions of the brain that may be susceptible to RA are those that continue to generate new neurons. In the adult mouse, neurogenesis is maintained in the hippocamp...

Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain the proliferative capacity of VZ resident progenitors remain elusive. We reveal that Sonic hedgehog (Shh) signaling is active in the cerebellar VZ and essential to radial glial cell proliferation and expansion of GABAergic interneurons. We demonstrate ...

It provides background information on the role of capital markets in PPP financing, and their principal advantages and disadvantages compared to traditional bank financing. It then reviews the dominant delivery model for PPP bonds, the so-called " monoline model " , and the impact of the downgrading of the monolines' rating following the credit crisis. The paper further analyses the reasons why...

The correct determination of deformation capacity of a structural member will become more important in the future since nonlinear design methods will be used more often. This report deals with the examination of deformation capacity of the concrete compression zone. The influence of size and the effect of transversal reinforcement of prisms under eccentric compression on their deformation capac...

We developed a technique of diaphragm imaging by using spiral computed tomography, and we studied four normal subjects who had been previously investigated with magnetic resonance imaging (A. P. Gauthier, S. Verbanck, M. Estenne, C. Segebarth, P. T. Macklem, and M. Paiva. J. Appl. Physiol. 76: 495-506, 1994). One acquisition of 15- to 25-s duration was performed at residual volume, functional r...

Introduction and Aim: Diabetic nephropathy is the common cause of final stage kidney disease. Studies on trace elements oxidant-antioxidant status in diabetes mellitus are required for establishing mechanisms involved pathogenesis diabetic complications, also to establish biomarkers addition conventional markers. The present study aimed assess correlate blood levels copper, iron, ceruloplasmin,...