Background and objectives: Melasma is one of the most common pigmentary disorders. It has a considerable impact on quality of life. The treatment of melasma has still remained a challenge because the efficient treatment has not been proven until now and there is still a need to find new depigmenting products.Allium cepa L. and Cucumis melo L. seeds as well as ...

background: the prevalence of denture stomatitis has been shown to vary from 15 to 65% in complete denture wearers. satureja hortensis l. has been considered to have antinociceptive, antiinflammatory, antifungal and antimicrobial activities in vitro and exhibits strong inhibitory effect on the growth of periodontal bacteria. the aim of this study was to evaluate the efficacy of a 1% gel formula...

There is a demand for pain relief during photodynamic therapy. We therefore investigated the efficacy and side-effects of topical morphine gel 0.3% for pain relief during topical photodynamic therapy in a randomized, double-blind, placebo-controlled study. The study involved 28 patients with actinic keratoses or basal cell carcinomas. Each patient was treated with photodynamic therapy after sup...

An effective anti-human immunodeficiency virus-1 (HIV-1) microbicide should exert its action in the absence of causing aberrant activation of topical immunity that will increase the risk of HIV acquisition. In the present study, we demonstrated that the vaginal application of cellulose sulfate (CS) gel induced topical mucosal inflammatory responses; the addition of minocycline to CS gel could s...

The development of the quality bioadhesive is an interesting subject to be studied. This study aims improve starch-based using olive oil. high content phenolic functional groups makes opportunity for oil used as additive adhesive. was made by hydrolysis, oxidation, polymerization, and addition. viscosity measurement, solid dry wet shear strength analysis were carried out determine bioadhesive. ...

External beam radiotherapy with high doses provokes many acute skin reactions, such as erythema and moist desquamation. Many topical preparations are used in radiation oncology departments in the skin care. Sucralfate humid gel, a colloidal physical form of the anti-ulcer drug sucralfate, promotes epithelial regeneration and activates cell proliferation. Based on this knowledge, we performed a ...

NEW DRUGS Mirvasco for Rosacea Brimonidine topical gel 0.33% (Mirvasco, Galderma) has been approved for the topical treatment of the facial erythema of rosacea in adults 18 years of age and older. Applied once daily, the medication reduces redness of the face and lasts up to 12 hours. An alpha2-adrenergic agonist, brimonidine appears to constrict the dilated facial blood vessels, which reduces ...

The aim of the study was to examine the effect of topical vehicles on the in vivo human stratum corneum penetration of the antioxidant and skin photoprotective agent (-)-epigallocatechin-3-gallate (EGCG). Model oil-in-water (o/w) emulsion and gel formulations containing 1 % (m/m) EGCG were prepared and subjected to photodegradation studies in order to select excipients that minimize the light i...

An endeavor has been made to create buccoadhesive bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing recurrence. Tablets of Tizanidine hydrochloride were prepared by direct compression method using bioadhesive polymer tamarind seed gum with backing layer of ethyl cellulose. The ph...