The angiogenic phenotype is associated with increased tumor neovascularization and a state of vascular hyperpermeability to macromolecules. Angiogenesis inhibitors could reverse these processes, resulting in tumor capillaries that have normal membrane permeability. It was proposed that the switch from a hyperpermeable to a normal permeable state could have the untoward effect of decreasing tumo...

The fluorescent nucleotide 2',3'-trinitrophenyl-ATP (TNP-ATP) binds at the triphosphate substrate binding site of the large (Klenow) fragment of DNA polymerase I (Pol I) as detected by direct binding studies measuring the increase in fluorescence of this ligand (n = 1.0, KD = 0.07 microM). The enzyme-TNP-ATP complex binds Mg2+ and Mn2+ tightly (KD = 0.05 microM) as measured by an increase in fl...

The rearranged genes encoding immunoglobulin heavy (mu) and light (kappa) chains specific for the hapten 2,4,6-trinitrophenyl (Tnp) were introduced into a B-lymphoma line that bears surface IgG with an unknown specificity and expresses surface Ia molecules. A transformant expressing surface IgM specific for Tnp was obtained. The transformant was found to present Tnp-proteins to antigen (protein...

In clinical practice many wounds are slow to heal and difficult to manage. The recently introduced technique of topical negative pressure therapy (TNP) has been developed to try to overcome some of these difficulties. TNP applies a controlled negative pressure to the surface of a wound that has potential advantages for wound treatment and management. Although the concept itself, of using suctio...

Conducting polymers (CPs) have contributed significantly to the field of sensing. The sensing nitroaromatic compounds by fluorescence has recently gained more attention due its sensitivity and selectivity. In this study, polyaniline (PANI) was functionalized forming a polyaniline-Ag (PANI-Ag) composite used as fluorophore for nitro groups present in (NACs) such 2,4,6-trinitrophenol (picric acid...

Priming of BALB/c mice with phosphorylcholine-hemocyanin (PC-Hy) induces T helper cells that are detected in splenic fragment cultures responding to immunization with trinitrophenylated PC-binding myeloma proteins, TEPC 15 (TNP-T15) and MOPC 167 (TNP-M167). Trinitrophenylation did not alter the binding site, idiotype, or isotype of the antibodies as demonstrated by binding studies. To assay idi...

T cells from mice injected with picryl sulfonic acid (PSA) can inhibit the anti-trinitrophenyl (TNP) antibody responses of mice produced after skin painting with picryl chloride (PCl). This had unusual specificity because the cells could inhibit IgG PFC responses in draining lymph nodes by 90% without affecting anti-TNP IgE responses as measured by heterologous adoptive cutaneous anaphylaxis. A...

Two tetraphenylethylene-based fluorescent conjugated microporous polymers (TTTPT and TTDAT) were obtained by the Friedel−Crafts polymerization reactions catalysed CH3SO3H. In virtue of containing tetraphenylethylene, triphenylamine s-triazine units in their porous skeletons, resulting TTTPT TTDAT show excellent fluorescence sensing performance for trinitrophenol (TNP) with high quenching coeffi...

It is agued that there is crosslinguistic variation regarding what counts as a phase in the traditional Noun Prase (TNP) which tracks independent crosslinguistic variation regarding the categorial status of the TNP assumed under the DP/NP parameter, on which languages without articles lack DP. In particular, it is argued that DP is a phase in DP languages, and NP is a phase in NP languages. How...