Previous studies have indicated that at least part of the selection of proteins for degradation takes place at a binding site on ubiquitin-protein ligase, to which the protein substrate is bound prior to ligation to ubiquitin. It was also shown that proteins with free NH2-terminal alpha-NH2 groups bind better to this site than proteins with blocked NH2 termini (Hershko, A., Heller, H., Eytan, E...

Abnormalities in repolarization of the cardiac ventricular action potential can lead to life-threatening arrhythmias associated with long QT syndrome. The repolarization process depends upon the gating properties of potassium channels encoded by the human ether-à-go-go-related gene (HERG), especially those governing the rate of recovery from inactivation and the rate of deactivation. Previous s...

Polyamidoamine dendrimers, which can deliver drugs and genetic materials to resistant cells, are attracting increased research attention, but their transportation behavior in resistant cells remains unclear. In this paper, we performed a systematic analysis of the cellular uptake, intracellular transportation, and efflux of PAMAM-NH2 dendrimers in multidrug-resistant breast cancer cells (MCF-7/...

The effect of plasma on degradation of human growth hormonereleasing hormone (GRH) was examined in vitro and in vivo using high performance liquid chromatography (HPLC), radioimmunoassay (RIA), and bioassay. When GRH(1-44)-NH2 was incubated with human plasma, the t1/2 of total GRH immunoreactivity was 63 min (RIA). However, HPLC revealed a more rapid disappearance (t1/2, 17 min) ofGRH(144)-NH2 ...

A peptide gemini surfactant, 12-G(NH2)LG(NH2)-12, has been constructed with two dodecyl chains separately attached to the two terminals of a glutamic acid-lysine-glutamic acid peptide and the aggregation behavior of the surfactant was studied in aqueous solution. The 12-G(NH2)LG(NH2)-12 molecules form fiber-like precipitates around pH 7.0, and the precipitation range is widened on increasing th...

A hybrid composite based on metal-organic framework (MOF) was chemically fabricated by embedding the magnetic Fe3O4 nanoparticles within amino-functionalized porous La-MOF (MOF/NH2) to produce a highly efficient and reusable of MOF/NH2/Fe3O4. Different proper techniques were used for characterization surface morphology chemical arrangement prepared MOF/NH2/Fe3O4 composite. The results using var...

Herein we report that mixed zirconium-cerium-MOFs with amino-functionalized linkers (2-amino-1,4-benzenedicarboxylate, BDC-NH2, and 4-aminonaphthalene-2,6-dicarboxylate, NDC-NH2) act as effective non-noble-metal-based heterogeneous catalysts, for both the aerobic photooxidation of benzylic alcohols direct microwaves activation N-alkylation amines alcohols. The catalytic performance has been stu...

UNLABELLED The glucagon-like peptide-1 (GLP-1) receptors are important biomarkers for imaging pancreatic β-cell mass and detection of benign insulinomas. Using GLP-1 receptor antagonists, we aimed to eliminate the insulin-related side effects reported for all GLP-1 receptor agonists. Additionally, using a nonresidualizing tracer, (125)I-Bolton-Hunter-Exendin(9-39)NH2 ((125)I-BH-Ex(9-39)NH2), we...

The treatment of Sb (III) wastewater produced from mining activities is uniquely challenging and has therefore garnered increasing attention. Here, an amino-modified zirconium-based metal-organic framework material (UiO-66-NH2) its composites were loaded onto graphene oxide (GO@UiO-66-NH2) via the hydrothermal method, after which these materials used to adsorb in mine wastewater. effects adsorp...