The TMPRSS2 protein is an entry pathway for SARS-CoV-2, its expression up-regulated by testosterone. Men have 7 to 8 times higher serum testosterone than women. We propose that patients hospitalized with COVID-19, levels of testosterone, worse outcomes those lower levels.

The influenza virus surface protein hemagglutinin (HA) mediates the first step in the viral replication cycle, viral entry into target cells. For this, HA binds to cellular receptors, proteins or lipids modified with α-2,3 or α-2,6 sialic acid, and facilitates the fusion of the viral and the endosomal membrane – a process essential for infectious entry. However, the HAprotein is synthesized as ...

Gleason score 7 (GS7) prostate cancer [tumors with both Gleason patterns 3 (GP3) and 4 (GP4)] portends a significantly more aggressive tumor than Gleason score 6 (GS6). It is, therefore, critical to understand the molecular relationship of adjacent GP3 and GP4 tumor cell populations and relate molecular abnormalities to disease progression. To decipher molecular relatedness, we used laser captu...

African Americans (AAs) who have PCa typically have more aggressive disease and make up a disproportionate number of the disease deaths, relative to European Americans (EAs). TMPRSS2 translocations, a common event in EA patients, are exploited in diagnostic and prognostic settings, whereas they are diminished in frequency in AA men. Thus, these patients with TMPRSS2 fusion-negative disease repr...

PURPOSE Fusion of the TMPRSS2 gene with the ERG oncogene and aberrant DNA methylation patterns are commonly found in prostate cancer. The aim of this study was to analyze the relationship between ERG expression, DNA methylation of three biomarkers, and clinicopathologic features of prostate cancer. EXPERIMENTAL DESIGN Immunohistochemistry for ERG protein was conducted as a surrogate for TMPRS...

Background Epigallocatechin-3-gallate (EGCG) is a major ingredient of green tea (GT) and silibinin (SB), the active component of Silymarin presumably hold a potential to prevent pathogenomics. Prostate cancer exacerbation is triggered by fusion transcripts formed because of genomic instability induced by juxtapositioning of two genes. This chimeric transcript is implicated in androgen dependent...

UNLABELLED CXCR4 is a chemokine receptor that mediates invasion and metastasis. CXCR4 expression is transcriptionally regulated in cancer cells and is associated with aggressive prostate cancer phenotypes. Previously, we and others have shown that the transcription factor ERG regulates CXCR4 expression in prostate cancer cells and that androgens modulate CXCR4 expression via increasing ERG expr...