After a single oral dose of praziquantel with 250 ml of grapefruit juice, the area under the concentration-time curve and the maximum concentration in plasma of praziquantel (Cmax) were significantly increased (Cmax for water treatment, 637.71 +/- 128.5 ng/ml; and Cmax for grapefruit juice treatment, 1,037.65 +/- 305.7 ng/ml, P < 0.05). No statistically significant differences were found in the...

AIM γ-oryzanol (OZ) is a rich source of commercially-important bioactive phytochemicals, most of them of interest in nutrition, pharmacy and cosmetics. However, the poor solubility of OZ limited the use. In the paper, ultraviolet-visible (UV-Vis) analysis was conducted to analysis the solubilization of OZ under combined use of Tween 80 in vitro. In addition, to further confirm the solubilizing ...

Plasma and lipoprotein alpha-tocopherol concentrations of four patients with familial isolated vitamin E deficiency and six control subjects were observed for 4 d after an oral dose (approximately 15 mg) of RRR-alpha-tocopheryl acetate labeled with six deuterium atoms (d6-tocopherol). Chylomicron d6-tocopherol concentrations were similar in the two groups. d6-Tocopherol concentrations of plasma...

BACKGROUND We formulated mianserin suppositories for the treatment of delirium and evaluated their pharmacokinetics by measuring plasma drug concentrations in dogs and healthy human volunteers. METHODS Mianserin suppositories were prepared by a melting technique using Tetramide® tablets and Witepsol H-15 as the suppository base. Pharmacokinetics of this 30-mg mianserin preparation were evalua...

BACKGROUND Deep digital septic conditions represent some of the most refractory causes of severe lameness in cattle. The objective of this study was to determine the distribution of tulathromycin, gamithromycin and florfenicol into the synovial fluid of the metatarsophalangeal (MTP) joint of cattle after single subcutaneous administration of drug to evaluate the potential usefulness of these si...

Two contradictory phase diagrams have dominated the literature of high-Tc cuprate superconductors. Does pseudogap line cross superconducting Tc-dome or not? To answer, we revisited experimental magnetic susceptibility and knight shift four different compounds, La1−xSrxCuO4, Bi2Sr2Ca1−xYxCu2O8, Bi2Sr2CaCu2O8+y, YBa2Cu3O6+y, as a function temperature doping. The can be described by same for all m...

Evapotranspiration is sensitive to climate change. The main objective of this study was examine the response reference evapotranspiration (ET0) under various change scenarios using artificial neural networks and Canadian Earth System Model Second Generation (CanESM2). Hargreaves method used calculate ET0 for western, central, eastern parts Prince Edward Island their two input parameters: daily ...

Temperature rise is a concern for future agriculture in different regions of the globe. This study aimed to reveal changes and variabilities minimum temperature (Tmin) maximum (Tmax) monthly, seasonal, annual scale over Bangladesh using 40 General Circulation Models (GCMs) Coupled Model Intercomparison Project Phase 5 (CMIP5) two radiative concentration pathways (RCPs, RCP4.5 RCP8.5). The stati...

Abstract: Response Surface Methodology (RSM) is introduced to optimize the control rod positions in a pressurized water reactor (PWR) core. The widely used 3D-IAEA benchmark problem is selected as the typical PWR core and the neutron flux field is solved. Besides, some additional thermal parameters are assumed to obtain the temperature distribution. Then the total and local entropy production i...