Monitoring unstable slopes with terrestrial laser scanning (TLS) has been proven effective. However, end users still struggle immensely with the efficient processing, analysis, and interpretation of the massive and complex TLS datasets. Two recent advances described in this paper now improve the ability to work with TLS data acquired on steep slopes. The first is the improved processing of TLS ...

We describe a largely automated and systematic analysis of TLS implementations by what we call ‘protocol state fuzzing’: we use state machine learning to infer state machines from protocol implementations, using only blackbox testing, and then inspect the inferred state machines to look for spurious behaviour which might be an indication of flaws in the program logic. For detecting the presence...

Tumor lysis syndrome (TLS) complicating non-hematologic malignancy is infrequent and spontaneous TLS is a very rare occurrence in patients with solid tumors. We report a case of spontaneous TLS in a patient with metastatic melanoma. Clinicians should have awareness of the possibility of spontaneous TLS in patients with solid tumors and should recognize the clinical presentation and laboratory t...

TLS (translocation in liposarcoma), an RNA-binding protein, was originally identified as a heterogeneous ribonuclear protein (hnRNP). Recently, we showed that TLS is localized in neuronal dendrites of mouse hippocampal neurons and is translocated to the spines, where local translation takes place, in an mGluR5 activation-dependent manner. However, the specific role of TLS has not been clarified...

The TLS-CHOP oncoprotein, found in the majority of human myxoid liposarcomas, consists of a fusion between the transcription factor CHOP/GADD153 and the N terminus of an RNA-binding protein TLS/FUS. Clinical correlation and in vitro transformation assays indicate that the N terminus of TLS plays an important role in oncogenesis by TLS-CHOP. Until now, however, the only activity attributed to th...

An internet user wanting to share observed content is typically restricted to primitive techniques such as screenshots, web caches or share button-like solutions. These acclaimed proofs, however, are either trivial to falsify or require trust in centralized entities (e.g., search engine caches). This motivates the need for a seamless and standardized internet-wide non-repudiation mechanism, all...

Tumor lysis syndrome (TLS) is widely recognized as a serious adverse event associated with the cytotoxic therapies primarily used in hematologic cancers, such as Burkitt lymphoma and acute lymphoblastic leukemia. In recent years, TLS has been more widely observed, due at least in part to the availability of more effective cancer treatments. Moreover, TLS is seen with greater frequency in solid ...

The TLS/FUS gene is involved in a recurrent chromosomal translocation in human myxoid liposarcomas. We previously reported that TLS is a potential splicing regulator able to modulate the 5'-splice site selection in an E1A pre-mRNA. Using an in vitro selection procedure, we investigated whether TLS exhibits a specificity with regard to RNA recognition. The RNAs selected by TLS share a common GGU...

An in vitro gas production technique was used to investigate the associative effects of untreated or biologically-treated linen straw with berseem hay (H). The linen straw (LS) was biologically treated with white rot fungi (TLS). Ground samples (200 mg DM) of H, LS, TLS and the mixtures (50% w/w) of H + LS and H + TLS were incubated in 100 ml glass syringes with buffered rumen fluid. Cumulative...