The most widely used secure Internet communication standard TLS (Transport Layer Security) has an optional client certificate authentication feature that in theory has significant security advantages over HTML form-based password authentication. In this paper we discuss practical security and usability issues related to TLS client certificate authentication stemming from the server side and bro...

Flexibility is one of the main strengths of the TLS protocol. Clients and servers can negotiate cipher suites to meet specific security and administrative policies. However, to date, authentication in TLS is limited only to public key solutions. As a result, TLS does not fully support organizations with heterogeneous security deployments that include authentication systems based on symmetric cr...

Tumor lysis syndrome (TLS) is characterized by hyperuricaemia, hyperphosphatemia, hyperkalaemia, as well as hypocalcaemia due to the breakdown of tumor cells undergoing cancer therapy (chemo/radio). Therefore it is of interest to evaluate oxidative stress using selective biological markers [Malondialdehyde (MDA), Superoxide Dismutase (SOD), Glutathione (GSH) and Catalase (CAT)] in TLS. We repor...

Total least squares (TLS) is a data modelling technique which can be used for many types of statistical analysis, e.g. a regression. In the regression setup, both dependent and independent variables are considered to be measured with errors. Thereby, the TLS approach in statistics is sometimes called an errors-invariables (EIV) modelling and, moreover, this type of regression is usually known a...

Protection of Internet communication is becoming more common in many products, as the demand for privacy in an age of state-level adversaries and crime syndicates is steadily increasing. The industry standard for doing this is TLS. The TLS protocol supports a multitude of key agreement and authentication options which provide various different security guarantees. Recent attacks showed that thi...

Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherap...

This technical note presents limits on the security (as a function of the number of plaintext bytes encrypted and the number of forgery attempts made by an adversary) for the main Authenticated Encryption schemes available in TLS 1.2 and the draft of TLS 1.3. These limits are derived from security proofs for the considered schemes available in the literature. Our intention is to provide conside...

We present a security analysis of the complete TLS protocol in the Universal Composablesecurity framework. This analysis evaluates the composition of key exchange functionalitiesrealized by the TLS handshake with the message transmission of the TLS record layer to em-ulate secure communication sessions and is based on the adaption of the secure channel modelfrom Canetti and Kraw...

Formation of intracellular aggregates is the hallmark of polyglutamine (polyQ) diseases. We analyzed the components of purified nuclear polyQ aggregates by mass spectrometry. As a result, we found that the RNA-binding protein translocated in liposarcoma (TLS) was one of the major components of nuclear polyQ aggregate-interacting proteins in a Huntington disease cell model and was also associate...

Cyclobutane pyrimidine dimers (CPDs) constitute the most frequent UV-induced DNA photoproduct. However, it has remained unclear how human and other mammalian cells mitigate the mutagenic and carcinogenic potential of CPDs emanating from their replicative bypass. Here, we examine in human cells the roles of translesion synthesis (TLS) DNA polymerases (Pols) in the replicative bypass of a cis-syn...