BACKGROUND Previous studies have demonstrated that the presence of serum IgA antibodies against actin filaments (AAA) in patients with celiac disease (CD) is strongly associated with mucosal damage and severe degrees of villous atrophy.The aims of the present study were (1) to verify the effectiveness of IgA-AAA in newly diagnosed CD patients in a clinical setting (2) to compare the immunofluor...

BACKGROUND & OBJECTIVES Several autoimmune disorders have been reported to be associated with autoimmune thyroiditis and may coexist with other organ-specific autoantibodies. The aim of the present study was to evaluate the presence of tissue transglutaminase (anti-TTG) and glutamic acid decarboxylase (anti-GAD) antibodies in patients suffering from autoimmune thyroiditis as diagnosed by anti-t...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: the prevalence of irritable bowel syndrome (ibs) in the community is 10%–20% and have symptom based diagnostic criteria. many symptoms of celiac disease (cd) with 1% prevalence in some communities can mimic ibs. sensitive and specific serologic tests of cd can detect asymptomatic cases. the purpose of this stud...

Tissue transglutaminase (tTG) is a marker for apoptosis, and its protein level is known to be increased in post-mortem Alzheimer's and Huntington's disease brains. tTG is increased in the cerebrospinal fluid of patients with Alzheimer's disease. However, the influence of psychotropic medication on acute cell death has not been studied so far in vivo, although some experiments performed in vitro...

Ghrelin and leptin are two hormones that possess multiple functions, including appetite regulation, maintenance of the tissue homeostasis regulation proinflammatory cytokines. A few studies on serum ghrelin levels in autoimmune diseases have exhibited conflicting results. Therefore, present study aimed to investigate relationship between energy balance diseases. Serum were assessed 94 adult pat...

multiple sclerosis (ms) is an autoimmune inflammatory process that affects the central nervous system (cns). celiac disease (cd) is a systemic autoimmune disorder of gluten intolerance. based on the presumed association of ms with multiple autoimmune processes, the coincidence of ms with gluten sensitivity has been investigated with controversial results. here, we report a known case of ms with...

BACKGROUND We measured anti-transglutaminase (anti-tTG) antibody in the culture medium of intestinal biopsy specimens from patients with suspected celiac disease (CD) and evaluated the relationship between antibody production and severity of intestinal mucosal damage. METHODS We performed diagnostic testing for CD on 273 consecutive patients. In addition to routine histologic evaluation of du...