RATIONALE AND OBJECTIVES To investigate the feasibility of recent contrast-specific ultrasound techniques in depicting vascular flow and the effects of changing the output power of the transducer and insonation mode on contrast enhancement, the authors performed an experimental study with a flow phantom. METHODS While changing the mechanical index and the sound insonation mode (continuous and...

Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e.g. by extending into higher frequencies and taking advantage of harmonic pheno...

High harmonic generation (HHG) is an established means of producing coherent, short wavelength, ultrafast pulses from a compact set-up. Table-top high-harmonic sources are increasingly being used to image physical and biological systems using emerging techniques such as coherent diffraction imaging and ptychography. These novel imaging methods require coherent illumination, and it is therefore ...

Background/introduction MR-ARFI adds to the rich toolbox of MR imaging methods for guiding focused ultrasound. MRI has exquisite soft tissue contrast for targeting focused ultrasound and a variety of contrast mechanisms for assessing the effect of focused ultrasound. In addition, MR can provide temperature mapping in near-realtime. MR-ARFI is an imaging method that compliments these other capab...

The ability to obtain comprehensive structural and functional information from intact biological tissue in vivo is highly desirable for many important biomedical applications, including cancer and brain studies. Here, we developed a fully integrated multimodal microscopy that can provide photoacoustic (optical absorption), two-photon (fluorescence), and second harmonic generation (SHG) informat...

The nonlinear optical effect, such as two-photon (Denk et al., 1990) and three-photon (Maiti et al., 1997; Schrader et al., 1997; Wokosin et al., 1996) fluorescence significantly improved the depth resolution and reduced the background noise. The nonlinear optical techniques have been used to develop a new generation of optical microscopes with novel capabilities. These new capabilities include...

Magnetomotive optical coherence tomography (MM-OCT) can be utilized to spatially localize the presence of magnetic particles within tissues or organs. These magnetic particle-containing regions are detected by using the capability of OCT to measure small-scale displacements induced by the activation of an external electromagnet coil typically driven by a harmonic excitation signal. The constrai...

The ability to respond to injury with tissue repair is a fundamental property of all multicellular organisms. The extracellular matrix (ECM), composed of fibrillar collagens as well as a number of other components is dis-regulated during repair in many organs. In many tissues, scaring results when the balance is lost between ECM synthesis and degradation. Investigating what disrupts this balanc...

OBJECTIVE To compare the detection rate of conventional ultrasonography and contrast-enhanced wide-band harmonic ultrasonographic imaging in the detection of small liver metastases. METHODS Consecutive patients with histologically proved gastrointestinal carcinoma liver metastases were studied. Biphasic helical computed tomography, conventional ultrasonography, and contrast-enhanced wide-band...