Regenerative medicine and tissue engineering have seen unprecedented growth in the past decade, driving the field of artificial tissue models towards a revolution in future medicine. Major progress has been achieved through the development of innovative biomanufacturing strategies to pattern and assemble cells and extracellular matrix (ECM) in three-dimensions (3D) to create functional tissue c...

Owing to the inability of self-replacement by a damaged myocardium, alternative strategies to heart transplantation have been explored within the last decades and cardiac tissue engineering/regenerative medicine is among the present challenges in biomedical research. Hopefully, several studies witness the constant extension of the toolbox available to engineer a fully functional, contractile, a...

From an “over-engineering” era in which biomaterials played a central role, now it is observed to the emergence of “developmental” tissue engineering (TE) strategies rely on integrative cell-material perspective that paves way for cell self-organization. The current challenge engineer microenvironment without hampering spontaneous collective arrangement ability cells, while simultaneously provi...

Hydrogels are three-dimensional polymeric networks filled with water and mimic tissue environments. Therefore, they are considered optimal to deliver cells and engineer damaged tissues. The hydrogel networks have been significantly modified to endow biochemical functionality with adhesive ligands, growth factors, or degradable sites that are helpful to drive proper cell functions. Recently, som...

UNLABELLED The three main key elements used in tissue engineering are the stem cells, morphogens and the scaffolds that, under a conductive external influence (environment) combine in the engineering of tissues. Part 1 of this two-part review article described in detail the various stem cells, morphogens and scaffolds that can be used in tissue engineering. This second article describes the var...

Engineering organs and tissues with the spatial composition and organisation of their native equivalents remains a major challenge. One approach to engineer such spatial complexity is to recapitulate the gradients in regulatory signals that during development and maturation are believed to drive spatial changes in stem cell differentiation. Mesenchymal stem cell (MSC) differentiation is known t...

Dynamic cell-microenvironment interactions regulate many biological events and play a critical role in tissue regeneration. Cell homing to targeted tissues requires well balanced interactions between cells and adhesion molecules on blood vessel walls. However, many stem cells lack affinity with adhesion molecules. It is challenging and clinically important to engineer these stem cells to modula...

In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we overlay triple-layer cardiac cell sheets produced from coculture with endothel...

The hygiene tissue industry has an extensive global market that is quickly growing. Market research indicated softness one of consumers’ most highly desired properties. For certain products (specifically bath tissue), this property can influence prices. A better understanding the science would allow companies to engineer soft more economically and efficiently. Softness a subjective perception r...