The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs...

Objective(s): Evaluate the effect of topical antiglaucoma drugs on tear film and determine the time taken to develop symptoms and or signs of dry eye in diagnosed open angle glaucoma patients by Schirmer's test I, Schirmer's test II, Tear film break up time. Method(s): This prospective study was carried out in 60 patients attending Ophthalmology outdoor with newly diagnosed patients of primary ...

The combination of anti-glaucoma eye drops is frequently used in clinical treatment, and it is known that the combination can cause corneal damage. Recently, an anti-glaucoma combination eye drops is developed, and the treatment by the combination eye drops is expected to enhance quality of life. However, effects of the combination eye drops on corneal epithelial cell damage have not been clari...

OBJECTIVE To compare the long-term effects of dorzolamide hydrochloride (Trusopt, Merck and Co Inc, White-house Station, NJ), timolol maleate, and betaxolol hydrochloride on corneal endothelial cell density and corneal thickness. METHODS This 1-year multicenter study was conducted in 298 patients with ocular hypertension or open-angle glaucoma who had a baseline central corneal endothelial ce...

Ocular tension of cats was measured after topical administration of the selective beta 1-adrenergic agonist CGP 7760B, the selective beta 1-adrenergic antagonist atenolol, the selective beta 2-adrenergic agonist salbutamol, the selective beta 2-adrenergic antagonist H 35/25, and the mixed beta 1- and beta 2-adrenergic antagonist timolol. Although atenolol did not alter intraocular pressure, CGP...

The beta-adrenergic antagonist timolol reduces ciliary epithelial secretion in glaucomatous patients. Whether inhibition is mediated by reducing cAMP is unknown. Elemental composition of rabbit ciliary epithelium was studied by electron probe X-ray microanalysis. Volume of cultured bovine pigmented ciliary epithelial (PE) cells was measured by electronic cell sizing; Ca(2+) activity and pH were...

The ability of topical timolol and epinephrine to decrease the 0-adrenergic responsiveness of the cornea and iris-ciliary body of albino and pigmented rabbits is reported. The time course of the decrease in responsiveness was determined by comparing in vitro, /?-adrenergic stimulated cyclic AMP synthesis in these tissues from in vivo drug treated and contralateral, untreated eyes. In the cornea...

A patient with chronic glaucoma and a history of contact allergic dermatitis to topical ophthalmic , adrenergic blocking drugs developed persistent ocular symptoms despite avoidance of , blockers. He was further investigated for possible allergy to pilocarpine. Case report A 70-year-old man presented with a persistent itch involving his eyes and a stinging and burning sensation aggravated by in...

Background: Migraine is manifested by recurrent headache attacks, with variable characteristics and associated symptoms. Oral beta blockers are widely used to prevent reduce the frequency these attacks. However, use of topical for acute treatment still controversial. Aims: In this randomized double – armed study, we aim compare efficacy Timolol 0.5% eyedrops compared other over-the-counter (OTC...

PURPOSE To compare the efficacy and safety of latanoprost, bimatoprost, travoprost and timolol in reducing intraocular pressure (IOP) in patients with primary open angle glaucoma. METHODS This was a prospective study conducted at a tertiary-care centre. One hundred and forty patients with newly diagnosed primary open angle glaucoma were randomly assigned to treatment with latanoprost (0.005%)...