Three mammalian nuclear lamin proteins, lamin B(1), lamin B(2) and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise r...

background: clinically frank thyroid nodules are common and believed to be present in 4% to 10% of the adult population in the united states. in the current literature, fine needle aspiration biopsies are considered to be the milestone of a model which helps the physician decide whether a certain thyroid nodule needs a surgical approach or not. a considerable fact is that sensitivity and specif...

according to its superficial anatomical location, the thyroid gland is easily accessible by sonography. sonography allows an exact documentation of the size and thyroid volume. the relationship between thyroid volume and anthropometric characteristics is a matter of controversy. the aim of this study was to investigate thyroid volume and its determinants in healthy adult. a cross-sectional stud...

thyroid cancer, the most common endocrine malignancy worldwide, originates from follicular epithelial cells. it is classified as a well-differentiated thyroid carcinoma (wdtc), which includes both follicular (ftc) and papillary types (ptc), poorly differentiated thyroid carcinomas (pdtc), anaplastic thyroid carcinoma (atc), and/or arising from para-follicular calcitonin producing cells involve m...