Dendrostellera lessertii (Thymelaeaceae) is a toxic plant that grows in parts of Iran. The anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-HK), have been established using several cancer cell lines. Methods: In a further attempt to determine the mode of action, two groups of synchronously growing cells were treated with a sin...

BACKGROUND Aqueous preparations of a medicinal plant, Gnidia stenophylla Gilg (Thymelaeaceae) are commonly used to cure malaria and other ailments in Ethiopia. This study evaluated the safety of the plant extract by determining its effects on food intake and histology of gastrointestinal tract (GIT) after oral administration for 13 weeks in albino mice. METHODS Thirty mice were equally assign...

ETHNOPHARMACOLOGICAL RELEVANCE Stellera chamaejasme L. (Thymelaeaceae) was a toxic perennial herb and widely used as pesticide and dermatological agents in China. Chamaechromone was a major component in the dried roots of Stellera chamaejasme with anti-HBV and insecticidal activity. Analysis of metabolic profile in vivo and in vitro plays a pivotal role to unravel how TCM works. And the metabol...

T eight species of Acomys have an extremely wide distribution, occurring in arid regions from southern Pakistan through the Middle East and most of Africa to the Cape (Nowak 1991). Two species are recognized within southern Africa, the spiny mouse A. spinosissimus, and the Cape spiny mouse A. subspinosus (Dippenaar & Rautenbach 1986). A. subspinosus has a restricted range (de Graaff 1997) and i...

The anticancer agents from plant sources usually exert their action through a wide range of mechanisms. As part of our studies of plants for new anticancer agents with emphasis on Thymelaeaceae family, we examined the cytotoxicity and anti-tumor activity of the water extract of D. mucronata leaves against induced breast tumor in rats. In the current study, we were interested to obtain some know...

Abstrak Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) atau suku gaharu-gaharuan adalah salah satu anggota tumbuhan berbunga. Berdasarkan literature penelitian, tanaman mahkota mengandung senyawa alkaloid, saponin, flavonoid, lignin (polifenol, flenoida, minyak atsiri dan tannin). Kebaruan dalam penelitian ini melakukan uji toksisitas buah pada Larva Nyamuk Culex Sp. Studi bertujuan mengin...

The anticancer agents from plant sources usually exert their action through a wide range of mechanisms. As part of our studies of plants for new anticancer agents with emphasis on Thymelaeaceae family, we examined the cytotoxicity and anti-tumor activity of the water extract of D. mucronata leaves against induced breast tumor in rats. In the current study, we were interested to obtain some know...