H/ACA RNA-guided ribonucleoprotein particle (RNP), the most complicated RNA pseudouridylase so far known, uses H/ACA guide RNA for substrate capture and four proteins (Cbf5, Nop10, L7Ae and Gar1) for pseudouridylation. Although it was shown that Gar1 not only facilitates the product release, but also enhances the catalytic activity, the chemical role that Gar1 plays in this complicated machiner...

QUESTION What is the lifetime and current prevalence of thumb problems in Australian physiotherapists and what are the factors associated with thumb problems? DESIGN Survey of a random cross-section of physiotherapists. PARTICIPANTS 1562(approximately 10% of the total) registered Australian physiotherapists. OUTCOME MEASURES General questions covered demographic information, area of pract...

38 Objective: The purpose of this study was to investigate altered finger-thumb coupling in 39 individuals with chronic hemiparesis post-stroke. 40 Methods: First, an external device stretched finger flexor muscles by passively rotating the 41 metacarpophalangeal (MCP) joints. Subjects then performed isometric finger or thumb force 42 generation. Forces/torques and electromyographic (EMG) signa...

BACKGROUND Over the last decade, image-guided production of three-dimensional (3D) haptic biomodels, or rapid prototyping (RP), has transformed the way surgeons conduct preoperative planning. In contrast to earlier RP techniques such as stereolithography, 3D printing has introduced fast, affordable office-based manufacturing. We introduce the concept of 4D printing for the first time by introdu...

2 Background Theory on Modeling 4 2.1 Modeling of 2DOF systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.1.1 Schematics and block diagram of experimental set up . . . . . . . . . 4 2.1.2 Dynamic model for 2DOF system . . . . . . . . . . . . . . . . . . . . 5 2.1.3 Comparison of rectilinear and torsional system . . . . . . . . . . . . . 6 2.2 Dynamic response of second order sy...

This case report presents a case of Fanconi's Anemia with an unusual thumb polydactyly in a 2-year-old boy. The extra thumb had no nail, nail bed and distal phalanx. The extra thumb had no active motion. The duplication of the thumb occurred at the carpometacarpal joint but its morphology did not match with any classification described for thumb polydactyly. Although his thumb polydactyly was a...

Perceptual estimates of three-dimensional (3D) properties, such as the distance and depth of an object, are often inaccurate. Given the accuracy and ease with which we pick up objects, it may be expected that perceptual distortions do not affect how the brain processes 3D information for reach-to-grasp movements. Nonetheless, empirical results show that grasping accuracy is reduced when visual ...

The neuromuscular blocking effect of repeated bolus administration of suxamethonium 1 mg/kg was observed in 10 healthy surgical patients under enflurane-nitrous oxide-oxygen anaesthesia. Tachyphylaxis and slow recovery of the thumb twitch occurred in close dose-relationships with transition of Phase I block to Phase II, using train-of-four fade as an indicator of the transition. Failure of the ...

The purpose of this study was to investigate altered finger-thumb coupling in individuals with chronic hemiparesis poststroke. First, an external device stretched finger flexor muscles by passively rotating the metacarpophalangeal (MCP) joints. Subjects then performed isometric finger or thumb force generation. Forces/torques and electromyographic signals were recorded for both the thumb and fi...