Metastatic colorectal cancer to the liver develops in over 50,000 US patients each year and is rapidly fatal if untreated. Even the most active chemotherapeutic agents rarely prolong survival for more than 3 years. Liver resection is the only potentially curative treatment, affording 5-year survival in one-third of patients. The only absolute contraindications to liver resection are poor genera...

Liver cancer is the fifth most commonly diagnosed cancer and the third most common cause of death from cancer worldwide; moreover the liver is the second most commonly involved organ by metastatic disease. A precise analysis of the lesions would help in the staging of the tumor and in the evaluation of the possible applicable therapies. In this paper we present the workflow developed for the se...

It was recently shown (Emery, 1952) that in approximately a third of children dying within the first few days of birth there was microscopic evidence of degeneration of parenchymal cells in the left physiological lobe of the liver. This change was not seen in stillborn children and was seen with increasing rareness in older children. It was suggested then that the changes were due to cessation ...

Six hundred sixty-seven first, second, and third orthotopic liver allografts in 520 patients were reviewed to determine the effect of recipient panel-reactive antibody (PRA) and donor-recipient antibody crossmatch on 2-year patient and liver allograft survival rates. Neither a high panel-reactive antibody nor a positive crossmatch for donor-specific preformed antIbody was associated with decrea...

Hepatic progenitor cells (HPCs) appear in response to several types of chronic injury in the human and rodent liver that often develop into liver fibrosis, cirrhosis, and primary liver cancers. However, the contribution of HPCs to the pathogenesis and progression of such liver diseases remains controversial. HPCs are generally defined as cells that can differentiate into hepatocytes and cholang...

Synchronous or metachronous liver metastases occur in up to one-third of patients with colorectal cancer and are associated with a poor prognosis. Many evidences have shown that surgical resection can be curative, with 5-year survival rates ranging from 37% to 50%, but many patients are ineligible for surgery because of multiple liver lesions, bilobar distribution of liver metastases, or the pr...

The aim: to study some histopathological changes in the liver affected by steatohepatitis of various etiologies with presence anemia. Material and methods. Liver biopsies were analyzed 30 patients non-alcoholic (NASH) 20 alcoholic (ASH). morphological examination was carried out according standard features established on basis hematoxylin eosin staining method, confirmation, if necessary, histo...

Systemic sarcoidosis is a disease of unknown etiology, with the liver being the third most commonly affected organ. Most cases of hepatic sarcoidosis are not clinically apparent, but a few can progress to liver cirrhosis, portal hypertension and ultimately liver failure. The diagnosis of hepatic sarcoidosis is difficult, considering that no single laboratory test or radiographic finding can def...

UNLABELLED Nonalcoholic steatohepatitis (NASH) is the commonest liver disease in developed countries. However, there are no current data on the cost-effectiveness of therapeutic options such as lifestyle modification, pioglitazone, or vitamin E. We undertook a cost utility analysis to compare these strategies. Using a third-party payer perspective, a deterministic Markov model was developed to ...

BACKGROUND : Oxidative stress may be one of the mechanisms for development complications in DM and many forms CKD. However, influence this factor on metabolism sialoglycoconjugates, which actively participates regulatory processes body, is unknown. AIM comparative study effect lipoic acid parameters liver sialoglycoconjugate rats with alloxan diabetes mellitus. MATERIALS AND METHODS Studies wer...